Growth response relationship between growth hormone dose and short term growth in patients with turner’s syndrome

Judith Levine Ross, Lauren Myerson Long, Marilyn Skerda, Fernando Cassorla, D. Lynn Loriaux, Gordon B. Cutler

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Short stature is a common feature of Turner's syndrome. We studied the dose-response relationship between short term linear growth and GH dose using the lower legmeasuring device. Three doses of GH (0.05, 0.15, and 0.45 U/kg, three times weekly) were given sc for 1-month treatment periods. Lower leg growth rate increased significantly during treatment with the 0.15 and 0.45 U/kg doses [1.8 ± 0.2 (±SEM) and 1.7 ± 0.3 mm/4 weeks). The higher dose of 0.45 U/kg was no more effective than the 0.15 U/kg dose. Serum somatomedin-C levels increased after treatment with each of the three doses of GH, but did not differ in any of the three dosage groups. We conclude that 0.15 U/kg GH, three times weekly, stimulates short term growth in patients with Turner’s syndrome. Longer term studies are required to determine if this increased growth rate is sustained.

Original languageEnglish (US)
Pages (from-to)1028-1030
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume63
Issue number4
DOIs
StatePublished - Oct 1986

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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