Growth in growth hormone insensitivity

Arlan L. Rosenbloom, Jaime Guevara-Aguirre, Ron G. Rosenfeld, Brad H. Pollock

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.

Original languageEnglish (US)
Pages (from-to)296-303
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume5
Issue number7
DOIs
StatePublished - Sep 1994

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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