Growth hormone insensitivity syndromes: Lessons learned and opportunities missed

Ronald (Ron) Rosenfeld, Caroline K. Buckway

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The concept of growth hormone (GH) insensitivity has evolved since the condition was originally identified in 1966, and we now know that the primary defect involved is in the GH receptor. Cloning of the receptor molecule has led to great progress in our understanding of GH insensitivity (GHI) and its therapy, including the roles of GH and insulin-like growth factor I (IGF-I) in growth and development, and the relationships between height and serum levels of GH, IGF-I and their binding proteins. Despite the success of work on GHI and IGF-I, a number of opportunities have been missed in the past. The differences between the metabolic effects of GH and IGF-I are not fully understood, while measurements of IGF-I and IGF-binding protein 3 are perhaps not the ideal means of diagnosing GHI. Finally, the use of IGF-I to treat GHI has a number of limitations, and work is underway to develop alternative therapies.

Original languageEnglish (US)
Pages (from-to)36-39
Number of pages4
JournalHormone Research
Volume55
Issue numberSUPPL. 2
StatePublished - 2001

Fingerprint

Laron Syndrome
Insulin-Like Growth Factor I
Growth Hormone
Somatotropin Receptors
Insulin-Like Growth Factor Binding Protein 3
Complementary Therapies
Growth and Development
Organism Cloning
Carrier Proteins
Serum

Keywords

  • Growth hormone
  • Growth hormone insensitivity
  • Insulin-like growth factor binding protein 3
  • Insulin-like growth factor I

ASJC Scopus subject areas

  • Endocrinology

Cite this

Rosenfeld, R. R., & Buckway, C. K. (2001). Growth hormone insensitivity syndromes: Lessons learned and opportunities missed. Hormone Research, 55(SUPPL. 2), 36-39.

Growth hormone insensitivity syndromes : Lessons learned and opportunities missed. / Rosenfeld, Ronald (Ron); Buckway, Caroline K.

In: Hormone Research, Vol. 55, No. SUPPL. 2, 2001, p. 36-39.

Research output: Contribution to journalArticle

Rosenfeld, RR & Buckway, CK 2001, 'Growth hormone insensitivity syndromes: Lessons learned and opportunities missed', Hormone Research, vol. 55, no. SUPPL. 2, pp. 36-39.
Rosenfeld, Ronald (Ron) ; Buckway, Caroline K. / Growth hormone insensitivity syndromes : Lessons learned and opportunities missed. In: Hormone Research. 2001 ; Vol. 55, No. SUPPL. 2. pp. 36-39.
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