Growth hormone effects on glucose metabolism

David Dunger, Kevin Yuen, Burak Salgin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: The increased risk for development of type 2 diabetes mellitus (T2DM) in adults with growth hormone deficiency (GHD) has been attributed to insulin resistance arising from increased visceral fat accumulation and the putative effects of low insulin-like growth factor I (IGF-I) levels on pancreatic β-cell mass and insulin secretion. Failure of GH replacement to reverse these abnormalities may reflect nonphysiological GH replacement or inability of the β-cell to recover. Methods and Results: We have demonstrated in normal subjects and in those with GHD that very low doses of GH can improve postabsorptive insulin sensitivity in direct relation to increased free IGF-I, reduce fasting glucose levels and potentially improve β-cell secretory capacity. Conclusions: These low doses of GH should prevent the development of T2DM in adult subjects, but this needs to be confirmed by long-term studies.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalHormone Research
Volume67
Issue numberSUPPL. 1
DOIs
StatePublished - Feb 1 2007

Keywords

  • Growth hormone
  • Growth hormone deficiency
  • Insulin secretion
  • Insulin sensitivity
  • Insulin-like growth factor I

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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