Growth hormone dosing variables in growth hormone-deficient adults

David M. Cook, Kevin C J Yuen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The use of growth hormone (GH) replacement for GH-deficient adults is now in its 10th year of FDA-approved use in the United States; it has been used for a longer period of time in some European countries. Despite widespread experience, there is still lack of consensus regarding the best approach to GH initiation and titration in adults with growth hormone deficiency. Several factors must be considered prior to dose selection, including patient age, gender, symptoms, and the use and route of estrogen replacement therapy. We retrospectively examined GH dosing practices within our institution over a 5-year period to define GH dose requirements during the initial titration and maintenance phases, the frequency of dose adjustments, and the reasons behind the dose adjustments in young and older adults. Based on this review, we offer practical recommendations for endocrinologists in the management of adults with hypopituitarism and long-term GH treatment.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalGrowth Hormone and IGF Research
Volume16
Issue numberSUPPL.
DOIs
StatePublished - Jul 2006

Fingerprint

Growth Hormone
Hypopituitarism
Estrogen Replacement Therapy
Patient Selection
Young Adult
Maintenance

Keywords

  • Adult
  • Dose adjustment
  • Growth hormone deficiency
  • Safety

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Growth hormone dosing variables in growth hormone-deficient adults. / Cook, David M.; Yuen, Kevin C J.

In: Growth Hormone and IGF Research, Vol. 16, No. SUPPL., 07.2006, p. 49-54.

Research output: Contribution to journalArticle

Cook, David M. ; Yuen, Kevin C J. / Growth hormone dosing variables in growth hormone-deficient adults. In: Growth Hormone and IGF Research. 2006 ; Vol. 16, No. SUPPL. pp. 49-54.
@article{6169ea76cbfd4847bcc7946cb672852c,
title = "Growth hormone dosing variables in growth hormone-deficient adults",
abstract = "The use of growth hormone (GH) replacement for GH-deficient adults is now in its 10th year of FDA-approved use in the United States; it has been used for a longer period of time in some European countries. Despite widespread experience, there is still lack of consensus regarding the best approach to GH initiation and titration in adults with growth hormone deficiency. Several factors must be considered prior to dose selection, including patient age, gender, symptoms, and the use and route of estrogen replacement therapy. We retrospectively examined GH dosing practices within our institution over a 5-year period to define GH dose requirements during the initial titration and maintenance phases, the frequency of dose adjustments, and the reasons behind the dose adjustments in young and older adults. Based on this review, we offer practical recommendations for endocrinologists in the management of adults with hypopituitarism and long-term GH treatment.",
keywords = "Adult, Dose adjustment, Growth hormone deficiency, Safety",
author = "Cook, {David M.} and Yuen, {Kevin C J}",
year = "2006",
month = "7",
doi = "10.1016/j.ghir.2006.03.007",
language = "English (US)",
volume = "16",
pages = "49--54",
journal = "Endocrinology and Metabolism, Supplement",
issn = "1096-6374",
publisher = "Churchill Livingstone",
number = "SUPPL.",

}

TY - JOUR

T1 - Growth hormone dosing variables in growth hormone-deficient adults

AU - Cook, David M.

AU - Yuen, Kevin C J

PY - 2006/7

Y1 - 2006/7

N2 - The use of growth hormone (GH) replacement for GH-deficient adults is now in its 10th year of FDA-approved use in the United States; it has been used for a longer period of time in some European countries. Despite widespread experience, there is still lack of consensus regarding the best approach to GH initiation and titration in adults with growth hormone deficiency. Several factors must be considered prior to dose selection, including patient age, gender, symptoms, and the use and route of estrogen replacement therapy. We retrospectively examined GH dosing practices within our institution over a 5-year period to define GH dose requirements during the initial titration and maintenance phases, the frequency of dose adjustments, and the reasons behind the dose adjustments in young and older adults. Based on this review, we offer practical recommendations for endocrinologists in the management of adults with hypopituitarism and long-term GH treatment.

AB - The use of growth hormone (GH) replacement for GH-deficient adults is now in its 10th year of FDA-approved use in the United States; it has been used for a longer period of time in some European countries. Despite widespread experience, there is still lack of consensus regarding the best approach to GH initiation and titration in adults with growth hormone deficiency. Several factors must be considered prior to dose selection, including patient age, gender, symptoms, and the use and route of estrogen replacement therapy. We retrospectively examined GH dosing practices within our institution over a 5-year period to define GH dose requirements during the initial titration and maintenance phases, the frequency of dose adjustments, and the reasons behind the dose adjustments in young and older adults. Based on this review, we offer practical recommendations for endocrinologists in the management of adults with hypopituitarism and long-term GH treatment.

KW - Adult

KW - Dose adjustment

KW - Growth hormone deficiency

KW - Safety

UR - http://www.scopus.com/inward/record.url?scp=33745221649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745221649&partnerID=8YFLogxK

U2 - 10.1016/j.ghir.2006.03.007

DO - 10.1016/j.ghir.2006.03.007

M3 - Article

C2 - 16624604

AN - SCOPUS:33745221649

VL - 16

SP - 49

EP - 54

JO - Endocrinology and Metabolism, Supplement

JF - Endocrinology and Metabolism, Supplement

SN - 1096-6374

IS - SUPPL.

ER -