The authors studied 80 eyes of patients with choroidal neovascular membranes (CNVMs) associated with age-related macular degeneration between 1982 and 1988. In each case, fluorescein angiography was done on two occasions separated by an interval of 2 days to 11 weeks (average, 13 days) without intervening photocoagulation. Forty-three CNVMs (54%) grew toward the fovea during the interval between fluorescein angiograms, with growth rates ranging from 1 to 24 μm daily (average, 10 μm daily). The CNVM growth was related to the time interval between angiograms (P < 0.0001), but was not associated with morphologic features of the CNVM. These results reinforce the need for early detection and prompt evaluation of elderly patients with symptoms of CNVMs.
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