TY - JOUR
T1 - Growth deficiency and malnutrition in Bloom syndrome
AU - Keller, Charles
AU - Keller, Kelly R.
AU - Shew, Stephen B.
AU - Plon, Sharon E.
PY - 1999
Y1 - 1999
N2 - Objectives: To describe the growth and nutritional status of a pediatric population with Bloom syndrome. Study design: Longitudinal growth data from 148 patients in the Bloom's Syndrome Registry (85 male, 63 female) were compiled retrospectively from physician and parent records to develop graphed statistics of weight-for-age, height-for-age, fronto-occipital circumference- for-age, and weight-for-height for both sexes with comparisons with the normal population. Results: Term birth measurements confirm that the growth deficiency of Bloom syndrome has prenatal onset. Stunting persists throughout life, and an adolescent growth spurt is not apparent from the smoothed data. Growth continues by at least 1 cm/yr until age 21 years for both sexes. More than half of children with Bloom syndrome are significantly wasted until age 8 years, which is not related to early death or underlying malignancy. The mean body mass index for adults with Bloom syndrome after age 25 years is low normal (n = 22, mean = 20.2 kg/m2). Conclusions: Children with Bloom syndrome have significant growth retardation and wasting.
AB - Objectives: To describe the growth and nutritional status of a pediatric population with Bloom syndrome. Study design: Longitudinal growth data from 148 patients in the Bloom's Syndrome Registry (85 male, 63 female) were compiled retrospectively from physician and parent records to develop graphed statistics of weight-for-age, height-for-age, fronto-occipital circumference- for-age, and weight-for-height for both sexes with comparisons with the normal population. Results: Term birth measurements confirm that the growth deficiency of Bloom syndrome has prenatal onset. Stunting persists throughout life, and an adolescent growth spurt is not apparent from the smoothed data. Growth continues by at least 1 cm/yr until age 21 years for both sexes. More than half of children with Bloom syndrome are significantly wasted until age 8 years, which is not related to early death or underlying malignancy. The mean body mass index for adults with Bloom syndrome after age 25 years is low normal (n = 22, mean = 20.2 kg/m2). Conclusions: Children with Bloom syndrome have significant growth retardation and wasting.
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U2 - 10.1016/S0022-3476(99)70206-4
DO - 10.1016/S0022-3476(99)70206-4
M3 - Article
C2 - 10190923
AN - SCOPUS:0033511453
SN - 0022-3476
VL - 134
SP - 472
EP - 479
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -