Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats

Farahnaz S. Joarder, Hussein Abou-Issa, Fredika M. Robertson, Michelle L. Parrett, Galal Alshafie, Randall E. Harris

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We examined effects of ibuprofen on the growth and development of DMBA- induced mammary cancers in mature female Sprague-Dawley rats. Ibuprofen was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reduction in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p<0.001). These results suggest that ibuprofen may have potential in the chemoprevention and treatment of breast cancer.

Original languageEnglish (US)
Pages (from-to)1271-1273
Number of pages3
JournalOncology Reports
Volume4
Issue number6
DOIs
StatePublished - 1997

Keywords

  • Ibuprofen
  • Mammary cancer
  • NSAIDs
  • Sprague-Dawley rat

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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