Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats

Farahnaz Joarder, Hussein Abou-Issa, Fredika M. Robertson, Michelle L. Parrett, Galal Alshafie, Randall E. Harris

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We examined effects of ibuprofen on the growth and development of DMBA- induced mammary cancers in mature female Sprague-Dawley rats. Ibuprofen was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reduction in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p

Original languageEnglish (US)
Pages (from-to)1271-1273
Number of pages3
JournalOncology Reports
Volume4
Issue number6
StatePublished - Nov 1997
Externally publishedYes

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9,10-Dimethyl-1,2-benzanthracene
Ibuprofen
Sprague Dawley Rats
Carcinogenesis
Breast
Tumor Burden
Growth
Growth and Development
Rodentia
Breast Neoplasms
Diet

Keywords

  • Ibuprofen
  • Mammary cancer
  • NSAIDs
  • Sprague-Dawley rat

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Joarder, F., Abou-Issa, H., Robertson, F. M., Parrett, M. L., Alshafie, G., & Harris, R. E. (1997). Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats. Oncology Reports, 4(6), 1271-1273.

Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats. / Joarder, Farahnaz; Abou-Issa, Hussein; Robertson, Fredika M.; Parrett, Michelle L.; Alshafie, Galal; Harris, Randall E.

In: Oncology Reports, Vol. 4, No. 6, 11.1997, p. 1271-1273.

Research output: Contribution to journalArticle

Joarder, F, Abou-Issa, H, Robertson, FM, Parrett, ML, Alshafie, G & Harris, RE 1997, 'Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats', Oncology Reports, vol. 4, no. 6, pp. 1271-1273.
Joarder F, Abou-Issa H, Robertson FM, Parrett ML, Alshafie G, Harris RE. Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats. Oncology Reports. 1997 Nov;4(6):1271-1273.
Joarder, Farahnaz ; Abou-Issa, Hussein ; Robertson, Fredika M. ; Parrett, Michelle L. ; Alshafie, Galal ; Harris, Randall E. / Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats. In: Oncology Reports. 1997 ; Vol. 4, No. 6. pp. 1271-1273.
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