Abstract
We examined effects of ibuprofen on the growth and development of DMBA- induced mammary cancers in mature female Sprague-Dawley rats. Ibuprofen was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reduction in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p<0.001). These results suggest that ibuprofen may have potential in the chemoprevention and treatment of breast cancer.
Original language | English (US) |
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Pages (from-to) | 1271-1273 |
Number of pages | 3 |
Journal | Oncology Reports |
Volume | 4 |
Issue number | 6 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
Keywords
- Ibuprofen
- Mammary cancer
- NSAIDs
- Sprague-Dawley rat
ASJC Scopus subject areas
- Oncology
- Cancer Research