Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro

Fang Zheng, Steven Johnson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Metabotropic glutamate receptor (mGluR) agonist t-ACPD produced concentration-dependent enhancement of NMDA/apamin-induced burst firing and membrane oscillations in dopamine cells, recorded intracellularly from ventral tegmental area in the rat midbrain slice. Such effects were blocked reversibly by mGluR antagonist MCPG, and mimicked by the selective agonist for group I (but not group II and III) mGluRs. Our results point out a selective involvement of group I mGluRs in facilitating burst firing of midbrain dopamine cells.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalBrain Research
Volume948
Issue number1-2
DOIs
StatePublished - Sep 6 2002

Fingerprint

Ventral Tegmental Area
Metabotropic Glutamate Receptors
Mesencephalon
Dopamine
Apamin
Excitatory Amino Acid Agonists
Excitatory Amino Acid Antagonists
N-Methylaspartate
Membranes
In Vitro Techniques
1-amino-1,3-dicarboxycyclopentane

Keywords

  • Dopamine cell
  • Metabotropic glutamate receptor
  • NMDA/apamin-induced burst
  • Ventral tegmental area

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro. / Zheng, Fang; Johnson, Steven.

In: Brain Research, Vol. 948, No. 1-2, 06.09.2002, p. 171-174.

Research output: Contribution to journalArticle

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