Group 5 metabotropic glutamate receptors: Role in modulating cortical activity and relevance to cognition

Houman Homayoun, Bita Moghaddam

Research output: Contribution to journalReview article

52 Scopus citations


Group 5 metabotropic glutamate (mGlu5) receptors are abundant in forebrain and limbic regions and provide a novel pharmacological target for modulation of cognition. Here, we review recent advances in understanding the electrophysiology of these receptors which reveal a role for mGlu5 receptors in the regulation of tonic and bursting modes of neuronal firing, maintenance of distinct forms of synaptic plasticity, and reversal of detrimental effects of NMDA receptor antagonism on cortical neuronal activity. Furthermore, recordings using recently developed positive allosteric modulators of the mGlu5 receptor suggest that these agents have an electrophysiological profile comparable to the antipsychotic agent clozapine. These findings, in conjunction with behavioral evidence from preclinical studies of cognition, suggest a potential precognitive profile for the mGlu5 receptor potentiators.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalEuropean Journal of Pharmacology
Issue number1-3
StatePublished - Aug 1 2010



  • Cognitive enhancer
  • Metabotropic glutamate receptor 5
  • NMDA glutamate receptor
  • Prefrontal cortex
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology

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