Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder

David F. Marshall, Sara Walker, Kelly A. Ryan, Masoud Kamali, Erika F H Saunders, Anne L. Weldon, Kenneth M. Adams, Melvin G. McInnis, Scott A. Langenecker

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Measures of cognitive dysfunction in Bipolar Disorder (BD) have identified state and trait dependent metrics. An influence of substance abuse (SUD) on BD has been suggested. This study investigates potential differential, additive, or interactive cognitive dysfunction in bipolar patients with or without a history of SUD. Two hundred fifty-six individuals with BD, 98 without SUD and 158 with SUD, and 97 Healthy Controls (HC) completed diagnostic interviews, neuropsychological testing, and symptom severity scales. The BD groups exhibited poorer performance than the HC group on most cognitive factors. The BD with SUD exhibited significantly poorer performance than BD without SUD in visual memory and conceptual reasoning/set-shifting. In addition, a significant interaction effect between substance use and depressive symptoms was found for auditory memory and emotion processing. BD patients with a history of SUD demonstrated worse visual memory and conceptual reasoning skills above and beyond the dysfunction observed in these domains among individuals with BD without SUD, suggesting greater impact on integrative, gestalt-driven processing domains. Future research might address longitudinal outcome as a function of BD, SUD, and combined BD/SUD to evaluate neural systems involved in risk for, and effects of, these illnesses.

Original languageEnglish (US)
Pages (from-to)252-257
Number of pages6
JournalPsychiatry Research
Volume200
Issue number2-3
DOIs
StatePublished - Dec 30 2012
Externally publishedYes

Fingerprint

Bipolar Disorder
Substance-Related Disorders
Emotions
Interviews
Depression
Control Groups

Keywords

  • Alcohol
  • Cognition
  • Dual diagnosis
  • Mood disorders
  • Neuropsychology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Marshall, D. F., Walker, S., Ryan, K. A., Kamali, M., Saunders, E. F. H., Weldon, A. L., ... Langenecker, S. A. (2012). Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder. Psychiatry Research, 200(2-3), 252-257. https://doi.org/10.1016/j.psychres.2012.06.013

Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder. / Marshall, David F.; Walker, Sara; Ryan, Kelly A.; Kamali, Masoud; Saunders, Erika F H; Weldon, Anne L.; Adams, Kenneth M.; McInnis, Melvin G.; Langenecker, Scott A.

In: Psychiatry Research, Vol. 200, No. 2-3, 30.12.2012, p. 252-257.

Research output: Contribution to journalArticle

Marshall, DF, Walker, S, Ryan, KA, Kamali, M, Saunders, EFH, Weldon, AL, Adams, KM, McInnis, MG & Langenecker, SA 2012, 'Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder', Psychiatry Research, vol. 200, no. 2-3, pp. 252-257. https://doi.org/10.1016/j.psychres.2012.06.013
Marshall, David F. ; Walker, Sara ; Ryan, Kelly A. ; Kamali, Masoud ; Saunders, Erika F H ; Weldon, Anne L. ; Adams, Kenneth M. ; McInnis, Melvin G. ; Langenecker, Scott A. / Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder. In: Psychiatry Research. 2012 ; Vol. 200, No. 2-3. pp. 252-257.
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