Gray matter differences between healthy and depressed adolescents: A voxel-based morphometry study

Mujeeb U. Shad, Srirangam Muddasani, Uma Rao

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Background: Major depressive disorder (MDD) frequently begins during adolescence and is associated with significant morbidity and mortality. However, little is known about the neurobiology of adolescent depression. A better understanding of the neurobiology will be helpful in developing more effective preventive and treatment interventions for this highly disabling illness. Methods: Using a voxel-based morphometric method, the study compared gray matter and white matter volumes in 22 adolescents with MDD and 22 age- and gender-matched normal controls. Results: Compared with controls, depressed adolescents had smaller gray matter volume in the frontal lobe and caudate nucleus bilaterally and right superior and middle temporal gyri. However, the groups did not differ significantly on white matter volume. Conclusions: These findings in depressed adolescents are consistent with the previous findings of gray matter abnormalities in frontolimbic areas and the striatum in depressed adults and suggest the presence of these structural changes at the onset of depressive illness.

Original languageEnglish (US)
Pages (from-to)190-197
Number of pages8
JournalJournal of Child and Adolescent Psychopharmacology
Volume22
Issue number3
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)

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