Granulomatous myocarditis. Diagnosis by endomyocardial biopsy and response to corticosteroids in two patients

E. O. McFalls, J. D. Hosenpud, J. H. McAnulty, Jack Kron, Nelson (Sam) Niles

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Granulomatous involvement of the myocardium is of uncertain etiology, rarely diagnosed premorbidly, and the response to therapy is unknown. We report two patients with granulomatous disease apparently isolated to the myocardium, one presenting with cardiac arrest secondary to ventricular tachycardia, one with heart block. In both cases, the clinical rhythm was substantiated by electrophysiologic studies and neither case had evidence of significant myocardial dysfunction. In both, treatment was instituted with orally administered prednisone. One patient died suddenly two months following onset of therapy. Limited autopsy demonstrated no evidence of granulomatous involvement of the myocardium. The other patient is alive without clinical arrhythmias on amiodarone therapy; however, inducible ventricular tachycardia persists. Repeat endomyocardial biopsy in this patient demonstrated no granulomatous disease. These cases are discussed and the literature reviewed.

Original languageEnglish (US)
Pages (from-to)509-511
Number of pages3
JournalChest
Volume89
Issue number4
StatePublished - 1986
Externally publishedYes

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Myocarditis
Adrenal Cortex Hormones
Biopsy
Myocardium
Ventricular Tachycardia
Heart Block
Amiodarone
Therapeutics
Prednisone
Heart Arrest
Cardiac Arrhythmias
Autopsy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

McFalls, E. O., Hosenpud, J. D., McAnulty, J. H., Kron, J., & Niles, N. S. (1986). Granulomatous myocarditis. Diagnosis by endomyocardial biopsy and response to corticosteroids in two patients. Chest, 89(4), 509-511.

Granulomatous myocarditis. Diagnosis by endomyocardial biopsy and response to corticosteroids in two patients. / McFalls, E. O.; Hosenpud, J. D.; McAnulty, J. H.; Kron, Jack; Niles, Nelson (Sam).

In: Chest, Vol. 89, No. 4, 1986, p. 509-511.

Research output: Contribution to journalArticle

McFalls, EO, Hosenpud, JD, McAnulty, JH, Kron, J & Niles, NS 1986, 'Granulomatous myocarditis. Diagnosis by endomyocardial biopsy and response to corticosteroids in two patients', Chest, vol. 89, no. 4, pp. 509-511.
McFalls EO, Hosenpud JD, McAnulty JH, Kron J, Niles NS. Granulomatous myocarditis. Diagnosis by endomyocardial biopsy and response to corticosteroids in two patients. Chest. 1986;89(4):509-511.
McFalls, E. O. ; Hosenpud, J. D. ; McAnulty, J. H. ; Kron, Jack ; Niles, Nelson (Sam). / Granulomatous myocarditis. Diagnosis by endomyocardial biopsy and response to corticosteroids in two patients. In: Chest. 1986 ; Vol. 89, No. 4. pp. 509-511.
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