Gram-negative bacillary endocarditis. Interpretation of the serum bactericidal test

Charles S. Bryan, Samuel R. Marney, Robert H. Alford, Richard Bryant

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Although the serum bactericidal test is commonly used in the management of infective endocarditis, little has been written about its validity or limitations. We report three cases of gram-negative bacillary endocarditis (Pseudomonas aeruginosa, Vibrio fetus and Serratia marcescens) encountered in 1 year at a Veterans Administration hospital. Serum bactericidal titers were considered necessary to identify inadequate antibiotic regimens or to avoid unnecessary drug toxicity. The limitations of the test, particularly those pertaining to gram-negative infections, are reviewed. Misleading results during treatment with aminoglycoside antibiotics could be due to the tendency of serum to become alkaline on standing. A detailed study of the interaction of the complement-dependent bactericidal system of serum with eight antibiotics is presented. In the context of the serum bactericidal test, the interaction was additive or synergistic in 15 of 16 determinations, indicating the need to include a control study of serum sensitivity of the infecting microorganism in each case.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalThe American journal of medicine
Volume58
Issue number2
DOIs
StatePublished - 1975
Externally publishedYes

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Serum Bactericidal Test
Endocarditis
Anti-Bacterial Agents
Serum
Campylobacter fetus
Veterans Hospitals
United States Department of Veterans Affairs
Serratia marcescens
Aminoglycosides
Drug-Related Side Effects and Adverse Reactions
Pseudomonas aeruginosa
Infection

ASJC Scopus subject areas

  • Nursing(all)

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Gram-negative bacillary endocarditis. Interpretation of the serum bactericidal test. / Bryan, Charles S.; Marney, Samuel R.; Alford, Robert H.; Bryant, Richard.

In: The American journal of medicine, Vol. 58, No. 2, 1975, p. 209-215.

Research output: Contribution to journalArticle

Bryan, Charles S. ; Marney, Samuel R. ; Alford, Robert H. ; Bryant, Richard. / Gram-negative bacillary endocarditis. Interpretation of the serum bactericidal test. In: The American journal of medicine. 1975 ; Vol. 58, No. 2. pp. 209-215.
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