Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalSteroids
Volume81
DOIs
StatePublished - Mar 2014

Keywords

  • 17β-Estradiol
  • Energy homeostasis
  • NPY/AgRP
  • POMC

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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