Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalSteroids
Volume81
DOIs
StatePublished - 2014

Fingerprint

Neurons
Pro-Opiomelanocortin
Neuropeptide Y
Peptides
Hypothalamus
Estradiol
Eating
Steroids
Cells
Hormones
Membranes
Population
Dasyproctidae

Keywords

  • 17β-Estradiol
  • Energy homeostasis
  • NPY/AgRP
  • POMC

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Molecular Biology
  • Organic Chemistry
  • Pharmacology

Cite this

Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons. / Smith, A. W.; Ronnekleiv, Oline; Kelly, Martin.

In: Steroids, Vol. 81, 2014, p. 31-35.

Research output: Contribution to journalArticle

@article{9e6306c8991443f4af6dc97ed1995fe0,
title = "Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons",
abstract = "Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.",
keywords = "17β-Estradiol, Energy homeostasis, NPY/AgRP, POMC",
author = "Smith, {A. W.} and Oline Ronnekleiv and Martin Kelly",
year = "2014",
doi = "10.1016/j.steroids.2013.11.007",
language = "English (US)",
volume = "81",
pages = "31--35",
journal = "Steroids",
issn = "0039-128X",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons

AU - Smith, A. W.

AU - Ronnekleiv, Oline

AU - Kelly, Martin

PY - 2014

Y1 - 2014

N2 - Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.

AB - Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.

KW - 17β-Estradiol

KW - Energy homeostasis

KW - NPY/AgRP

KW - POMC

UR - http://www.scopus.com/inward/record.url?scp=84895523670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895523670&partnerID=8YFLogxK

U2 - 10.1016/j.steroids.2013.11.007

DO - 10.1016/j.steroids.2013.11.007

M3 - Article

VL - 81

SP - 31

EP - 35

JO - Steroids

JF - Steroids

SN - 0039-128X

ER -