Abstract
This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin αIIbβ3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase Cγ2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1752-1762 |
| Number of pages | 11 |
| Journal | Journal of Thrombosis and Haemostasis |
| Volume | 3 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2005 |
| Externally published | Yes |
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Keywords
- Collagen
- GPVI
- Integrin
- Src kinases
- Syk
- Tyrosine kinases
ASJC Scopus subject areas
- Medicine(all)
Cite this
GPVI and integrin αIIbβ3 signaling in platelets. / Watson, S. P.; Auger, J. M.; McCarty, Owen; Pearce, A. C.
In: Journal of Thrombosis and Haemostasis, Vol. 3, No. 8, 2005, p. 1752-1762.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - GPVI and integrin αIIbβ3 signaling in platelets
AU - Watson, S. P.
AU - Auger, J. M.
AU - McCarty, Owen
AU - Pearce, A. C.
PY - 2005
Y1 - 2005
N2 - This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin αIIbβ3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase Cγ2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.
AB - This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin αIIbβ3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase Cγ2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.
KW - Collagen
KW - GPVI
KW - Integrin
KW - Src kinases
KW - Syk
KW - Tyrosine kinases
UR - http://www.scopus.com/inward/record.url?scp=26444535506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26444535506&partnerID=8YFLogxK
U2 - 10.1111/j.1538-7836.2005.01429.x
DO - 10.1111/j.1538-7836.2005.01429.x
M3 - Article
C2 - 16102042
AN - SCOPUS:26444535506
VL - 3
SP - 1752
EP - 1762
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
SN - 1538-7933
IS - 8
ER -