Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair

Amit Mogha, Breanne L. Harty, Dan Carlin, Jessica Joseph, Nicholas E. Sanchez, Ueli Suter, Xianhua Piao, Valeria Cavalli, Kelly Monk

Research output: Contribution to journalArticle

22 Scopus citations


Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood. We previously showed that the adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for SC development and myelination. Interestingly, the expression of Gpr126 is maintained in adult SCs, suggestive of a function in the mature nerve. We therefore investigated the role of Gpr126 in nerve repair by studying an inducible SC-specific Gpr126 knock-out mouse model. Here, we show that remyelination is severely delayed after nerve-crush injury. Moreover, we also observe non cell-autonomous defects in macrophage recruitment and axon regeneration in injured nerves following loss of Gpr126 in SCs. This work demonstrates that Gpr126 has critical SC-autonomous and SC-nonautonomous functions in remyelination and peripheral nerve repair.

Original languageEnglish (US)
Pages (from-to)12351-12367
Number of pages17
JournalJournal of Neuroscience
Issue number49
Publication statusPublished - Dec 7 2016
Externally publishedYes



  • Adhesion GPCR
  • Gpr126
  • Nerve injury
  • Remyelination
  • Schwann cell

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this