Go/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex

Sophie Bagur, Martin Averseng, DIego Elgueda, Stephen David, Jonathan Fritz, Pingbo Yin, Shihab Shamma, Yves Boubenec, Srdjan Ostojic

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Primary sensory cortices are classically considered to extract and represent stimulus features, while association and higher-order areas are thought to carry information about stimulus meaning. Here we show that this information can in fact be found in the neuronal population code of the primary auditory cortex (A1). A1 activity was recorded in awake ferrets while they either passively listened or actively discriminated stimuli in a range of Go/No-Go paradigms, with different sounds and reinforcements. Population-level dimensionality reduction techniques reveal that task engagement induces a shift in stimulus encoding from a sensory to a behaviorally driven representation that specifically enhances the target stimulus in all paradigms. This shift partly relies on task-engagement-induced changes in spontaneous activity. Altogether, we show that A1 population activity bears strong similarities to frontal cortex responses. These findings indicate that primary sensory cortices implement a crucial change in the structure of population activity to extract task-relevant information during behavior.

Original languageEnglish (US)
Article number2529
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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Auditory Cortex
cortexes
Health Services Needs and Demand
stimuli
Reinforcement
Association reactions
Acoustic waves
Population
Ferrets
Frontal Lobe
shift
reinforcement
bears
coding
acoustics

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Go/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex. / Bagur, Sophie; Averseng, Martin; Elgueda, DIego; David, Stephen; Fritz, Jonathan; Yin, Pingbo; Shamma, Shihab; Boubenec, Yves; Ostojic, Srdjan.

In: Nature Communications, Vol. 9, No. 1, 2529, 01.12.2018.

Research output: Contribution to journalArticle

Bagur, S, Averseng, M, Elgueda, DI, David, S, Fritz, J, Yin, P, Shamma, S, Boubenec, Y & Ostojic, S 2018, 'Go/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex', Nature Communications, vol. 9, no. 1, 2529. https://doi.org/10.1038/s41467-018-04839-9
Bagur, Sophie ; Averseng, Martin ; Elgueda, DIego ; David, Stephen ; Fritz, Jonathan ; Yin, Pingbo ; Shamma, Shihab ; Boubenec, Yves ; Ostojic, Srdjan. / Go/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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