Gonadotrophic and local control of the developing corpus luteum in rhesus monkeys

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    The actions of the mid-cycle gonadotrophin surge to convert the pre-ovulatory follicle into the corpus luteum are not well understood in primate species. In experiments titrating the surge duration required in macaque monkeys during artificial in-vitro fertilization (IVF)-related cycles, short (≤ 14 h) LH surges similar to those in rodents and domestic animals failed to initiate peri-ovulatory events. Attenuated (24 h) surges, one-half the duration of spontaneous surges in primates, reinitiated oocyte meiosis and initial luteinization of granulosa cells. However, only surges of ≥ 48 h sustained luteal development and function to produce luteal phases of ~13 days. Three approaches-immunocytochemistry of steroid receptors, binding of radiolabelled steroid, and reverse transcription-polymerase chain reaction of mRNA indicate that progesterone receptor (PR), but not oestrogen receptor, is expressed in the macaque corpus luteum. Studies on cells collected before and after the gonadotrophin surge identified a novel action of LH to induce PR expression in luteinizing granulosa cells. Thus, the LH surge requirements vary between non-primate and primate species, as well as between peri-ovulatory events, and the LH surge may promote cellular recognition of paracrine and autocrine factors (e.g. progesterone) that become predominant in the developing corpus luteum.

    Original languageEnglish (US)
    Pages (from-to)107-111
    Number of pages5
    JournalHuman Reproduction
    Volume8
    Issue numberSUPPL. 2
    StatePublished - 1993

    Fingerprint

    Corpus Luteum
    Macaca mulatta
    Primates
    Granulosa Cells
    Macaca
    Progesterone Receptors
    Gonadotropins
    Luteinization
    Steroid Receptors
    Luteal Phase
    Domestic Animals
    Meiosis
    Fertilization in Vitro
    Estrogen Receptors
    Reverse Transcription
    Oocytes
    Haplorhini
    Progesterone
    Rodentia
    Immunohistochemistry

    Keywords

    • Luteal development
    • Luteal function
    • Luteinizing hormone
    • Oestrogen receptors
    • Progesterone receptors

    ASJC Scopus subject areas

    • Developmental Biology
    • Physiology
    • Obstetrics and Gynecology
    • Reproductive Medicine

    Cite this

    Gonadotrophic and local control of the developing corpus luteum in rhesus monkeys. / Stouffer, Richard; Chandrasekher, Y. A.; Slayden, Ov; Zelinski, Mary.

    In: Human Reproduction, Vol. 8, No. SUPPL. 2, 1993, p. 107-111.

    Research output: Contribution to journalArticle

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