Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Malcolm J. Low, Ronald M. Lechan, Robert E. Hammer, Ralph L. Brinster, Joel F. Habener, Gail Mandel, Richard Goodman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

Original languageEnglish (US)
Pages (from-to)1002-1004
Number of pages3
JournalScience
Volume231
Issue number4741
StatePublished - 1986
Externally publishedYes

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Gonadotrophs
Metallothionein
Gene Fusion
Somatostatin
Transgenic Mice
Anterior Pituitary Gland
Human Growth Hormone

ASJC Scopus subject areas

  • General

Cite this

Low, M. J., Lechan, R. M., Hammer, R. E., Brinster, R. L., Habener, J. F., Mandel, G., & Goodman, R. (1986). Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science, 231(4741), 1002-1004.

Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. / Low, Malcolm J.; Lechan, Ronald M.; Hammer, Robert E.; Brinster, Ralph L.; Habener, Joel F.; Mandel, Gail; Goodman, Richard.

In: Science, Vol. 231, No. 4741, 1986, p. 1002-1004.

Research output: Contribution to journalArticle

Low, MJ, Lechan, RM, Hammer, RE, Brinster, RL, Habener, JF, Mandel, G & Goodman, R 1986, 'Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice', Science, vol. 231, no. 4741, pp. 1002-1004.
Low MJ, Lechan RM, Hammer RE, Brinster RL, Habener JF, Mandel G et al. Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science. 1986;231(4741):1002-1004.
Low, Malcolm J. ; Lechan, Ronald M. ; Hammer, Robert E. ; Brinster, Ralph L. ; Habener, Joel F. ; Mandel, Gail ; Goodman, Richard. / Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. In: Science. 1986 ; Vol. 231, No. 4741. pp. 1002-1004.
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