Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Malcolm J. Low; Ronald M. Lechan; Robert E. Hammer; Ralph L. Brinster; Joel F. Habener; Gail Mandel; Richard H. Goodman

doi:10.1126/science.2868526

Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Malcolm J. Low, Ronald M. Lechan, Robert E. Hammer, Ralph L. Brinster, Joel F. Habener, Gail Mandel, Richard H. Goodman

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

Original language	English (US)
Pages (from-to)	1002-1004
Number of pages	3
Journal	Science
Volume	231
Issue number	4741
DOIs	https://doi.org/10.1126/science.2868526
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.2868526

Cite this

@article{8882997b4e544bb6a16d0a5816f50fdb,

title = "Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice",

abstract = "Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.",

author = "Low, {Malcolm J.} and Lechan, {Ronald M.} and Hammer, {Robert E.} and Brinster, {Ralph L.} and Habener, {Joel F.} and Gail Mandel and Goodman, {Richard H.}",

year = "1986",

doi = "10.1126/science.2868526",

language = "English (US)",

volume = "231",

pages = "1002--1004",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4741",

}

TY - JOUR

T1 - Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

AU - Low, Malcolm J.

AU - Lechan, Ronald M.

AU - Hammer, Robert E.

AU - Brinster, Ralph L.

AU - Habener, Joel F.

AU - Mandel, Gail

AU - Goodman, Richard H.

PY - 1986

Y1 - 1986

N2 - Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

AB - Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

UR - http://www.scopus.com/inward/record.url?scp=0022462144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022462144&partnerID=8YFLogxK

U2 - 10.1126/science.2868526

DO - 10.1126/science.2868526

M3 - Article

C2 - 2868526

AN - SCOPUS:0022462144

SN - 0036-8075

VL - 231

SP - 1002

EP - 1004

JO - Science

JF - Science

IS - 4741

ER -

Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this