Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis

Bruce F. Bebo, Edy Zelinka-Vincent, Grazyna Adamus, Drake Amundson, Arthur A. Vandenbark, Halina Offner

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139-151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4+, Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE.

Original languageEnglish (US)
Pages (from-to)122-130
Number of pages9
JournalJournal of Neuroimmunology
Volume84
Issue number2
DOIs
StatePublished - Apr 15 1998

Keywords

  • Androgens
  • Orchidectomy
  • Relapsing experimental autoimmune encephalomyelitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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