TY - JOUR
T1 - Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis
AU - Bebo, Bruce F.
AU - Zelinka-Vincent, Edy
AU - Adamus, Grazyna
AU - Amundson, Drake
AU - Vandenbark, Arthur A.
AU - Offner, Halina
N1 - Funding Information:
We are grateful to Dr. David Hess for performing the serum hormone analysis, and Cantab Pharmaceuticals for providing the mouse OX40L-Ig fusion protein. We also thank Dr. Andrew Weinberg and Dr. Charles Roselli for helpful discussions and critical review of this manuscript. This work was supported by the Department of Veterans Affairs and by National Institutes of Health Grants NS 23221 AI42376 and NS23444. B.F.B. is a post-docotoral fellow of the National Multiple Sclerosis Society.
PY - 1998/4/15
Y1 - 1998/4/15
N2 - Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139-151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4+, Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE.
AB - Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139-151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4+, Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE.
KW - Androgens
KW - Orchidectomy
KW - Relapsing experimental autoimmune encephalomyelitis
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U2 - 10.1016/S0165-5728(97)00214-2
DO - 10.1016/S0165-5728(97)00214-2
M3 - Article
C2 - 9628453
AN - SCOPUS:0032522101
SN - 0165-5728
VL - 84
SP - 122
EP - 130
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 2
ER -