Golimumab for the treatment of axial spondyloarthritis

Gita Gelfer, Lisa Perry, Atul Deodhar

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Axial spondyloarthritis (axSpA) is a chronic, immune-mediated inflammatory disease of the axial skeleton that includes ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients with AS experience chronic pain due to sacroiliac joint and spinal inflammation, and may develop spinal ankylosing with syndesmophyte formation. Tumor necrosis factor α inhibitors (TNFi) have shown promise in the management of AS and axSpA by targeting the underlying inflammatory process, and providing symptomatic relief. Whether they alter the progression of the disease is uncertain. Golimumab is a fully human IgG1 monoclonal antibody that targets and downregulates the pro-inflammatory cytokine TNF-α. The use of golimumab has been shown to reduce the signs and symptoms of axSpA as well as improve patient function and quality reported outcomes. This review focuses on the biological rationale and the results of clinical trials with golimumab for the treatment of axSpA.

Original languageEnglish (US)
Pages (from-to)9-18
Number of pages10
JournalExpert Review of Clinical Immunology
Volume12
Issue number1
DOIs
StatePublished - Jan 2 2016

Keywords

  • Ankylosing spondylitis
  • TNF inhibitors
  • anti-tumor necrosis factor
  • axial spondyloarthritis
  • golimumab
  • nonradiographic axial spondyloarthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Golimumab for the treatment of axial spondyloarthritis'. Together they form a unique fingerprint.

  • Cite this