Glutamatergic Control of Dopamine Release During Stress in the Rat Prefrontal Cortex

Hank Peter Jedema, Bita Moghaddam

Research output: Contribution to journalArticle

85 Scopus citations


Abstract: In vivo microdialysis was used to assess the hypothesis that the stress‐induced increase in dopamine release in the prefrontal cortex is mediated by stress‐activated glutamate neurotransmission in this region. Local perfusion of an α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA)/kainate receptor antagonist, 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione, blocked the stress‐induced increase in dopamine levels, whereas an NMDA receptor antagonist, 2‐amino‐5‐phosphonopentanoic acid, at the dose tested, was not able to alter this response significantly. These data indicate that the effect of stress on dopamine release in the prefrontal cortex is mediated locally by activation of AMPA/kainate receptors, which modulate the release of dopamine in this region.

Original languageEnglish (US)
Pages (from-to)785-788
Number of pages4
JournalJournal of Neurochemistry
Issue number2
StatePublished - Aug 1994



  • Dopamine
  • Excitatory amino acids
  • Microdialysis
  • Prefrontal cortex
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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