Glutamatergic Control of Dopamine Release During Stress in the Rat Prefrontal Cortex

Hank Peter Jedema, Bita Moghaddam

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Abstract: In vivo microdialysis was used to assess the hypothesis that the stress‐induced increase in dopamine release in the prefrontal cortex is mediated by stress‐activated glutamate neurotransmission in this region. Local perfusion of an α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA)/kainate receptor antagonist, 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione, blocked the stress‐induced increase in dopamine levels, whereas an NMDA receptor antagonist, 2‐amino‐5‐phosphonopentanoic acid, at the dose tested, was not able to alter this response significantly. These data indicate that the effect of stress on dopamine release in the prefrontal cortex is mediated locally by activation of AMPA/kainate receptors, which modulate the release of dopamine in this region.

Original languageEnglish (US)
Pages (from-to)785-788
Number of pages4
JournalJournal of Neurochemistry
Volume63
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Prefrontal Cortex
Rats
Dopamine
Kainic Acid Receptors
Microdialysis
N-Methyl-D-Aspartate Receptors
Synaptic Transmission
Glutamic Acid
Perfusion
Chemical activation
Acids

Keywords

  • Dopamine
  • Excitatory amino acids
  • Microdialysis
  • Prefrontal cortex
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Glutamatergic Control of Dopamine Release During Stress in the Rat Prefrontal Cortex. / Jedema, Hank Peter; Moghaddam, Bita.

In: Journal of Neurochemistry, Vol. 63, No. 2, 1994, p. 785-788.

Research output: Contribution to journalArticle

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