Glutamate release monitored with astrocyte transporter currents during LTP

Jeffrey S. Diamond, Dwight E. Bergles, Craig Jahr

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release, heightened postsynaptic sensitivity, or a combination of the two. We have measured evoked glutamate release from Schaffer collateral/commissural fiber terminals in CA1 by recording synaptically activated glutamate transporter currents in hippocampal astrocytes located in stratum radiatum. Although several manipulations of release probability caused parallel changes in extracellular field potentials and synaptically activated transporter current amplitudes, induction of LTP failed to alter transporter-mediated responses, suggesting that LTP does not alter the amount of glutamate released upon synaptic stimulation.

Original languageEnglish (US)
Pages (from-to)425-433
Number of pages9
JournalNeuron
Volume21
Issue number2
StatePublished - Aug 1998

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Long-Term Potentiation
Astrocytes
Glutamic Acid
Hippocampus
Amino Acid Transport System X-AG
Synaptic Transmission

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Diamond, J. S., Bergles, D. E., & Jahr, C. (1998). Glutamate release monitored with astrocyte transporter currents during LTP. Neuron, 21(2), 425-433.

Glutamate release monitored with astrocyte transporter currents during LTP. / Diamond, Jeffrey S.; Bergles, Dwight E.; Jahr, Craig.

In: Neuron, Vol. 21, No. 2, 08.1998, p. 425-433.

Research output: Contribution to journalArticle

Diamond, JS, Bergles, DE & Jahr, C 1998, 'Glutamate release monitored with astrocyte transporter currents during LTP', Neuron, vol. 21, no. 2, pp. 425-433.
Diamond JS, Bergles DE, Jahr C. Glutamate release monitored with astrocyte transporter currents during LTP. Neuron. 1998 Aug;21(2):425-433.
Diamond, Jeffrey S. ; Bergles, Dwight E. ; Jahr, Craig. / Glutamate release monitored with astrocyte transporter currents during LTP. In: Neuron. 1998 ; Vol. 21, No. 2. pp. 425-433.
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