Glutamate release monitored with astrocyte transporter currents during LTP

Jeffrey S. Diamond, Dwight E. Bergles, Craig E. Jahr

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release, heightened postsynaptic sensitivity, or a combination of the two. We have measured evoked glutamate release from Schaffer collateral/commissural fiber terminals in CA1 by recording synaptically activated glutamate transporter currents in hippocampal astrocytes located in stratum radiatum. Although several manipulations of release probability caused parallel changes in extracellular field potentials and synaptically activated transporter current amplitudes, induction of LTP failed to alter transporter-mediated responses, suggesting that LTP does not alter the amount of glutamate released upon synaptic stimulation.

Original languageEnglish (US)
Pages (from-to)425-433
Number of pages9
JournalNeuron
Volume21
Issue number2
DOIs
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Neuroscience(all)

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