TY - JOUR
T1 - Glutamate receptors and excitotoxicity.
AU - Westbrook, G. L.
PY - 1993
Y1 - 1993
N2 - The features of central glutamate synapses are well suited to the spectrum of functions these elements serve in brain function. However, receptor-mediated mechanisms are only one facet of phenomena such as excitotoxicity or long-term potentiation, which almost certainly involve other neuronal components, e.g., other transmitter systems, voltage-gated channels, and biochemical mechanisms as well as possibly astrocytes in some cases. Nonetheless the rapid pace of progress in this field reinforces not only the diversity and complexity of the CNS, but suggests that it is not overly optimistic to think that understanding of these mechanisms will soon have an impact on neurological and mental illness.
AB - The features of central glutamate synapses are well suited to the spectrum of functions these elements serve in brain function. However, receptor-mediated mechanisms are only one facet of phenomena such as excitotoxicity or long-term potentiation, which almost certainly involve other neuronal components, e.g., other transmitter systems, voltage-gated channels, and biochemical mechanisms as well as possibly astrocytes in some cases. Nonetheless the rapid pace of progress in this field reinforces not only the diversity and complexity of the CNS, but suggests that it is not overly optimistic to think that understanding of these mechanisms will soon have an impact on neurological and mental illness.
UR - http://www.scopus.com/inward/record.url?scp=0027344067&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027344067&partnerID=8YFLogxK
M3 - Review article
C2 - 8380238
AN - SCOPUS:0027344067
SN - 0091-7443
VL - 71
SP - 35
EP - 50
JO - Research publications - Association for Research in Nervous and Mental Disease
JF - Research publications - Association for Research in Nervous and Mental Disease
ER -