Glutamate receptor update

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

The past year has seen significant advances in matching the actions of recombinant glutamate receptors with the actions of native receptors, and in mapping their distribution and regulation. The discovery of a novel RNA editing mechanism for AMPA receptors and a revised view of the transmembrane topology of the NMDA receptor subunit, NR1, are particularly noteworthy. Seven metabotropic glutamate receptor subtypes have been identified with several interesting expression patterns and transduction mechanisms; results from work on these subtypes has led to a provocative model of the ligand-binding site. Functional studies of metabotropic receptors have been enhanced by the development of the first subtype-specific antagonist.

Original languageEnglish (US)
Pages (from-to)337-346
Number of pages10
JournalCurrent Opinion in Neurobiology
Volume4
Issue number3
DOIs
StatePublished - Jun 1994

ASJC Scopus subject areas

  • Neuroscience(all)

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