Glutamate receptor desensitization and its role in synaptic transmission

Laurence Trussell, Gerald D. Fischbach

Research output: Contribution to journalArticle

335 Citations (Scopus)

Abstract

Responses of excitatory amino acid receptors to rapidly applied glutamate were measured in outside-out membrane patches from chick spinal neurons. The peak current varied with glutamate concentration, with a half-maximal response at 510 μM and a Hill coefficient near 2. Currents activated by 1 mM glutamate desensitized and recovered in two phases. The faster time constant was identical to the time constant of decay of synaptic currents, suggesting that glutamatergic synaptic currents are terminated, in part, by receptor desensitization. Steady-state desensitization was evident following application of only 2-3 μM glutamate, concentrations comparable to levels in the extracellular space in the intact brain. Thus, glutamate receptor desensitization can affect synaptic efficacy in two ways: at high concentrations, rapid desensitization of receptors may curtail synaptic currents; at low concentrations, there is a significant reduction in the number of activatable receptors.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalNeuron
Volume3
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

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Glutamate Receptors
Synaptic Transmission
Glutamic Acid
Extracellular Space
Neurons
Membranes
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Glutamate receptor desensitization and its role in synaptic transmission. / Trussell, Laurence; Fischbach, Gerald D.

In: Neuron, Vol. 3, No. 2, 1989, p. 209-218.

Research output: Contribution to journalArticle

Trussell, Laurence ; Fischbach, Gerald D. / Glutamate receptor desensitization and its role in synaptic transmission. In: Neuron. 1989 ; Vol. 3, No. 2. pp. 209-218.
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