Glucose transporters in parasitic protozoa.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Glucose and related hexoses play central roles in the biochemistry and metabolism of single-cell parasites such as Leishmania, Trypanosoma, and Plasmodium that are the causative agents of leishmaniasis, African sleeping sickness, and malaria. Glucose transporters and the genes that encode them have been identified in each of these parasites and their functional properties have been scrutinized. These transporters are related in sequence and structure to mammalian facilitative glucose transporters of the SLC2 family, but they are nonetheless quite divergent in sequence. Hexose transporters have been shown to be essential for the viability of the infectious stage of each of these parasites and thus may represent targets for development of novel anti-parasitic drugs. The study of these transporters also illuminates many aspects of the basic biology of Leishmania, trypanosomes, and malaria parasites.

Original languageEnglish (US)
Pages (from-to)245-262
Number of pages18
JournalMethods in molecular biology (Clifton, N.J.)
Volume637
DOIs
StatePublished - 2010

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Facilitative Glucose Transport Proteins
Parasites
Leishmania
Malaria
Monosaccharide Transport Proteins
African Trypanosomiasis
Trypanosoma
Hexoses
Leishmaniasis
Plasmodium
Trypanosomiasis
Biochemistry
Glucose
Pharmaceutical Preparations
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Glucose transporters in parasitic protozoa. / Landfear, Scott.

In: Methods in molecular biology (Clifton, N.J.), Vol. 637, 2010, p. 245-262.

Research output: Contribution to journalArticle

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