GLUCOSE PROMOTES WHOLE-BODY PROTEIN SYNTHESIS FROM INFUSED AMINOACIDS IN FASTING MAN. Isotopic Demonstration

A. J.W. Sim; V. R. Young; B. M. Wolfe; D. Clarke; F. D. Moore

doi:10.1016/S0140-6736(79)90062-X

GLUCOSE PROMOTES WHOLE-BODY PROTEIN SYNTHESIS FROM INFUSED AMINOACIDS IN FASTING MAN. Isotopic Demonstration

A. J.W. Sim, V. R. Young, B. M. Wolfe, D. Clarke, F. D. Moore

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

¹⁵N-glycine constant infusion, with plateau urea enrichment as the endpoint, demonstrated a clear increase in whole-body protein synthesis when glucose was added to aminoacid infusion in fasting men. Whole-body protein-breakdown rates remained unchanged. There was an unexpected fall in whole-body nitrogen turnover when the subjects were changed from an oral intake to either of the intravenous programmes: this finding, not previously reported, may be due to the decrease in gastrointestinal enzyme synthesis and intestinal-lining cell-turnover when oral intake is replaced by total parenteral nutrition.

Original language	English (US)
Pages (from-to)	68-72
Number of pages	5
Journal	The Lancet
Volume	313
Issue number	8107
DOIs	https://doi.org/10.1016/S0140-6736(79)90062-X
State	Published - Jan 13 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(79)90062-X

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title = "GLUCOSE PROMOTES WHOLE-BODY PROTEIN SYNTHESIS FROM INFUSED AMINOACIDS IN FASTING MAN. Isotopic Demonstration",

abstract = "15N-glycine constant infusion, with plateau urea enrichment as the endpoint, demonstrated a clear increase in whole-body protein synthesis when glucose was added to aminoacid infusion in fasting men. Whole-body protein-breakdown rates remained unchanged. There was an unexpected fall in whole-body nitrogen turnover when the subjects were changed from an oral intake to either of the intravenous programmes: this finding, not previously reported, may be due to the decrease in gastrointestinal enzyme synthesis and intestinal-lining cell-turnover when oral intake is replaced by total parenteral nutrition.",

author = "Sim, {A. J.W.} and Young, {V. R.} and Wolfe, {B. M.} and D. Clarke and Moore, {F. D.}",

note = "Funding Information: Supported in part by grants (AM 13526 and AM 20495) from the National Institutes of Health and by a grant from the Sugar Associ- ation. R.S.S. is the recipient of a Research Career Development Award (AM 0334) from the National Institutes of Health. Reprints should be addressed to R.S.S.",

year = "1979",

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doi = "10.1016/S0140-6736(79)90062-X",

language = "English (US)",

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AU - Sim, A. J.W.

AU - Young, V. R.

AU - Wolfe, B. M.

AU - Clarke, D.

AU - Moore, F. D.

N1 - Funding Information: Supported in part by grants (AM 13526 and AM 20495) from the National Institutes of Health and by a grant from the Sugar Associ- ation. R.S.S. is the recipient of a Research Career Development Award (AM 0334) from the National Institutes of Health. Reprints should be addressed to R.S.S.

PY - 1979/1/13

Y1 - 1979/1/13

N2 - 15N-glycine constant infusion, with plateau urea enrichment as the endpoint, demonstrated a clear increase in whole-body protein synthesis when glucose was added to aminoacid infusion in fasting men. Whole-body protein-breakdown rates remained unchanged. There was an unexpected fall in whole-body nitrogen turnover when the subjects were changed from an oral intake to either of the intravenous programmes: this finding, not previously reported, may be due to the decrease in gastrointestinal enzyme synthesis and intestinal-lining cell-turnover when oral intake is replaced by total parenteral nutrition.

AB - 15N-glycine constant infusion, with plateau urea enrichment as the endpoint, demonstrated a clear increase in whole-body protein synthesis when glucose was added to aminoacid infusion in fasting men. Whole-body protein-breakdown rates remained unchanged. There was an unexpected fall in whole-body nitrogen turnover when the subjects were changed from an oral intake to either of the intravenous programmes: this finding, not previously reported, may be due to the decrease in gastrointestinal enzyme synthesis and intestinal-lining cell-turnover when oral intake is replaced by total parenteral nutrition.

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GLUCOSE PROMOTES WHOLE-BODY PROTEIN SYNTHESIS FROM INFUSED AMINOACIDS IN FASTING MAN. Isotopic Demonstration

Abstract

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