GLUCOSE PROMOTES WHOLE-BODY PROTEIN SYNTHESIS FROM INFUSED AMINOACIDS IN FASTING MAN. Isotopic Demonstration

A. J.W. Sim, V. R. Young, B. M. Wolfe, D. Clarke, F. D. Moore

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

15N-glycine constant infusion, with plateau urea enrichment as the endpoint, demonstrated a clear increase in whole-body protein synthesis when glucose was added to aminoacid infusion in fasting men. Whole-body protein-breakdown rates remained unchanged. There was an unexpected fall in whole-body nitrogen turnover when the subjects were changed from an oral intake to either of the intravenous programmes: this finding, not previously reported, may be due to the decrease in gastrointestinal enzyme synthesis and intestinal-lining cell-turnover when oral intake is replaced by total parenteral nutrition.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalThe Lancet
Volume313
Issue number8107
DOIs
StatePublished - Jan 13 1979

ASJC Scopus subject areas

  • Medicine(all)

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