Glucocorticoids amplify glomerular injury in rats with renal ablation

D. L. Garcia, H. G. Rennke, B. M. Brenner, Sharon Anderson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Male Munich-Wistar rats were subjected to 1 2/3 nephrectomy. One group received no therapy (C). A second group received daily doses of methylprednisolone (MP). A third group received MP plus the angiotensin I converting enzyme inhibitor (CEI) benzazepril. A fourth group received CEI alone. Half of the rats in each group underwent micropuncture study 2 weeks after ablation. Untreated rats exhibited systemic hypertension and elevation of the single nephron glomerular filtration rate (SNGFR), due to glomerular capillary hyperperfusion and hypertension. Administration of MP resulted in comparable systemic hypertension with further elevation of SNGFR due to even higher values for glomerular perfusion and hydraulic pressure (P(GC)). Concurrent treatment with CEI-controlled systemic and glomerular hypertension despite equivalent renal ablation and comparable doses of MP. After 12 weeks untreated rats demonstrated continued systemic hypertension, progressive proteinuria, and eventual glomerular sclerosis. Addition of MP dramatically accelerated the development of proteinuria and glomerular sclerosis, while CEI afforded striking protection against disease progression. Thus, potent vasodilator glucocorticoids may amplify hemodynamically mediated glomerular injury, whereas control of systemic and glomerular hypertension prevents this undesirable consequence of chronic steroid therapy.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalAmerican Journal of Hypertension
Volume1
Issue number1
StatePublished - 1988
Externally publishedYes

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Glucocorticoids
Methylprednisolone
Hypertension
Kidney
Wounds and Injuries
Enzyme Inhibitors
Nephrons
Sclerosis
Glomerular Filtration Rate
Proteinuria
Nephrectomy
Vasodilator Agents
Punctures
Angiotensin-Converting Enzyme Inhibitors
Disease Progression
Wistar Rats
Therapeutics
Perfusion
Steroids
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Glucocorticoids amplify glomerular injury in rats with renal ablation. / Garcia, D. L.; Rennke, H. G.; Brenner, B. M.; Anderson, Sharon.

In: American Journal of Hypertension, Vol. 1, No. 1, 1988, p. 54-57.

Research output: Contribution to journalArticle

Garcia, D. L. ; Rennke, H. G. ; Brenner, B. M. ; Anderson, Sharon. / Glucocorticoids amplify glomerular injury in rats with renal ablation. In: American Journal of Hypertension. 1988 ; Vol. 1, No. 1. pp. 54-57.
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