Glucocorticoid therapy in the preleukemic syndrome (hemopoietic dysplasia). Identification of responsive patients using in-vitro techniques

G. C. Bagby, J. D. Gabourel, J. W. Linman

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    Abstract

    Bone marrow cells from 54 patients with the preleukemic syndrome were cultured in agar (granulocyte colony forming units) in the presence and absence of cortisol. Thirty-four patients were given trials of prednisone therapy after the initial culture was performed. Cortisol (in vitro) failed to enhance colony growth in 29 of these 34 cases, and none of the 29 patients responded to prednisone therapy. Cortisol enhanced colony growth in five patients and three of these responded favorably to prednisone therapy. The correlation of in-vivo with in-vitro events is significant (P

    Original languageEnglish (US)
    Pages (from-to)55-58
    Number of pages4
    JournalAnnals of Internal Medicine
    Volume92
    Issue number1
    StatePublished - 1980

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    Glucocorticoids
    Prednisone
    Hydrocortisone
    Therapeutics
    Growth
    Granulocytes
    Bone Marrow Cells
    Agar
    Stem Cells
    In Vitro Techniques

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Glucocorticoid therapy in the preleukemic syndrome (hemopoietic dysplasia). Identification of responsive patients using in-vitro techniques. / Bagby, G. C.; Gabourel, J. D.; Linman, J. W.

    In: Annals of Internal Medicine, Vol. 92, No. 1, 1980, p. 55-58.

    Research output: Contribution to journalArticle

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