Glucocortcoids mediate the stress-induced extracellular accumulation of glutamate

Bita Moghaddam, Maria L. Bolinao, Becky Stein-Behrens, Robert Sapolsky

Research output: Contribution to journalArticlepeer-review

355 Scopus citations


The hippocampal damage caused by stress has been attributed to an increased glutamatergic tone brought about by secretion of glococorticoids. Although exposure to stress has been shown to increase the outflow of glutamate, direct involvement of glucocorticoid in this phenomenon has not been examined. The present study demonstrates that adrenalectomy attenuates the stress-induced outflow of glutamate in the hippocampus and prefrontal cortex and that glucocorticoid replacement abolishes this attenuation.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalBrain research
Issue number1-2
StatePublished - Aug 29 1994
Externally publishedYes


  • Glucocorticoid
  • Glutamate
  • Hippocampus
  • Microdialysis
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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