Glucocortcoids mediate the stress-induced extracellular accumulation of glutamate

Bita Moghaddam; Maria L. Bolinao; Becky Stein-Behrens; Robert Sapolsky

doi:10.1016/0006-8993(94)91622-5

Glucocortcoids mediate the stress-induced extracellular accumulation of glutamate

Bita Moghaddam, Maria L. Bolinao, Becky Stein-Behrens, Robert Sapolsky

Research output: Contribution to journal › Article › peer-review

355 Scopus citations

Abstract

The hippocampal damage caused by stress has been attributed to an increased glutamatergic tone brought about by secretion of glococorticoids. Although exposure to stress has been shown to increase the outflow of glutamate, direct involvement of glucocorticoid in this phenomenon has not been examined. The present study demonstrates that adrenalectomy attenuates the stress-induced outflow of glutamate in the hippocampus and prefrontal cortex and that glucocorticoid replacement abolishes this attenuation.

Original language	English (US)
Pages (from-to)	251-254
Number of pages	4
Journal	Brain research
Volume	655
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(94)91622-5
State	Published - Aug 29 1994
Externally published	Yes

Keywords

Glucocorticoid
Glutamate
Hippocampus
Microdialysis
Stress

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)91622-5

Cite this

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title = "Glucocortcoids mediate the stress-induced extracellular accumulation of glutamate",

abstract = "The hippocampal damage caused by stress has been attributed to an increased glutamatergic tone brought about by secretion of glococorticoids. Although exposure to stress has been shown to increase the outflow of glutamate, direct involvement of glucocorticoid in this phenomenon has not been examined. The present study demonstrates that adrenalectomy attenuates the stress-induced outflow of glutamate in the hippocampus and prefrontal cortex and that glucocorticoid replacement abolishes this attenuation.",

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author = "Bita Moghaddam and Bolinao, {Maria L.} and Becky Stein-Behrens and Robert Sapolsky",

note = "Funding Information: This work was supportedi n part by PHS Awards MH48404 (BM), AGO6633 (RMS) and Departmento f VA National Center for PTSD.",

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AU - Stein-Behrens, Becky

AU - Sapolsky, Robert

N1 - Funding Information: This work was supportedi n part by PHS Awards MH48404 (BM), AGO6633 (RMS) and Departmento f VA National Center for PTSD.

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N2 - The hippocampal damage caused by stress has been attributed to an increased glutamatergic tone brought about by secretion of glococorticoids. Although exposure to stress has been shown to increase the outflow of glutamate, direct involvement of glucocorticoid in this phenomenon has not been examined. The present study demonstrates that adrenalectomy attenuates the stress-induced outflow of glutamate in the hippocampus and prefrontal cortex and that glucocorticoid replacement abolishes this attenuation.

AB - The hippocampal damage caused by stress has been attributed to an increased glutamatergic tone brought about by secretion of glococorticoids. Although exposure to stress has been shown to increase the outflow of glutamate, direct involvement of glucocorticoid in this phenomenon has not been examined. The present study demonstrates that adrenalectomy attenuates the stress-induced outflow of glutamate in the hippocampus and prefrontal cortex and that glucocorticoid replacement abolishes this attenuation.

KW - Glucocorticoid

KW - Glutamate

KW - Hippocampus

KW - Microdialysis

KW - Stress

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ER -

Glucocortcoids mediate the stress-induced extracellular accumulation of glutamate

Abstract

Keywords

ASJC Scopus subject areas

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