TY - JOUR
T1 - Glomerular and tubular basement membrane calcinosis
T2 - Case report and literature review
AU - Troxell, Megan L.
AU - Higgins, John P.
AU - Sibley, Richard K.
PY - 2006/2
Y1 - 2006/2
N2 - • Nephrocalcinosis most commonly manifests as renal calculi or deposition within the tubulointerstitial compartment. Conversely, calcium deposition within glomeruli is extremely rare. We present the case of a 50-year-old man with multiple medical problems, including hepatitis C, diabetes, hypertension, proteinuria, and chronic renal failure. Renal biopsy showed impressive calcium deposits along glomerular basement membranes and tubular basement membranes, within intracellular organelles, and in the interstitium in the setting of a normal serum calcium level. Seven months after biopsy, the patient is on hemodialysis therapy. Although serological and medical examination failed to show a treatable cause for this patient's glomerular calcinosis, individual case reports in the literature have described resolution of calcinosis-associated nephrotic syndrome with treatment of the primary cause of hypercalcemia.
AB - • Nephrocalcinosis most commonly manifests as renal calculi or deposition within the tubulointerstitial compartment. Conversely, calcium deposition within glomeruli is extremely rare. We present the case of a 50-year-old man with multiple medical problems, including hepatitis C, diabetes, hypertension, proteinuria, and chronic renal failure. Renal biopsy showed impressive calcium deposits along glomerular basement membranes and tubular basement membranes, within intracellular organelles, and in the interstitium in the setting of a normal serum calcium level. Seven months after biopsy, the patient is on hemodialysis therapy. Although serological and medical examination failed to show a treatable cause for this patient's glomerular calcinosis, individual case reports in the literature have described resolution of calcinosis-associated nephrotic syndrome with treatment of the primary cause of hypercalcemia.
KW - Calcinosis
KW - Diabetic nephropathy
KW - Metastatic calcification
KW - Proteinuria
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U2 - 10.1053/j.ajkd.2005.10.030
DO - 10.1053/j.ajkd.2005.10.030
M3 - Article
C2 - 16431246
AN - SCOPUS:31044434754
SN - 0272-6386
VL - 47
SP - e23-e26
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 2
ER -