Global Electrical Heterogeneity: Mechanisms and Clinical Significance

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

This review summarizes recent findings and discusses a clinical significance of a vectorcardiographic (VCG) Global electrical heterogeneity (GEH). GEH concept is based on the concept of the spatial ventricular gradient (SVG), which is a global measure of the dispersion of total recovery time. We quantify GEH by measuring five features of the SVG vector (SVG magnitude, direction (azimuth and elevation), a scalar value, and spatial QRS-T angle) on orthogonal XYZ ECG. In analysis of more than 20,000 adults we showed that GEH is independently associated with sudden cardiac death (SCD) after adjustment for demographics, cardiovascular disease (time-updated incident non-fatal cardiovascular events [coronary heart disease, heart failure, stroke, atrial fibrillation, use of beta-blockers], and known risk factors [cholesterol, triglycerides, physical activity index, smoking, diabetes, obesity, hypertension, antihypertensive medications, creatinine, alcohol intake, left ventricular ejection fraction, and time-updated ECG metrics (heart rate, QTc, QRS duration, ECG-left ventricular hypertrophy, bundle branch block or interventricular conduction delay)]. This finding suggests that GEH represents an independent electrophysiological substrate of SCD.

Original languageEnglish (US)
Title of host publicationComputing in Cardiology Conference, CinC 2018
PublisherIEEE Computer Society
ISBN (Electronic)9781728109589
DOIs
StatePublished - Sep 2018
Externally publishedYes
Event45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Netherlands
Duration: Sep 23 2018Sep 26 2018

Publication series

NameComputing in Cardiology
Volume2018-September
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Conference

Conference45th Computing in Cardiology Conference, CinC 2018
Country/TerritoryNetherlands
CityMaastricht
Period9/23/189/26/18

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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