Global ECG measures and cardiac structure and function the ARIC study (Atherosclerosis risk in communities)

Tor Biering-Sørensen, Muammar Kabir, Jonathan W. Waks, Jason Thomas, Wendy S. Post, Elsayed Z. Soliman, Alfred E. Buxton, Amil M. Shah, Scott D. Solomon, Larisa Tereshchenko

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    BACKGROUND: Electric excitation initiates myocardial mechanical contraction and coordinates myocardial pumping. We hypothesized that ECG global electric heterogeneity (GEH) and its longitudinal changes are associated with cardiac structure and function. METHODS AND RESULTS: Participants from the ARIC study (Atherosclerosis Risk in Communities) (N=5114; 58% female; 22% blacks) with resting 12-lead ECGs (visits 1–5) and echocardiographic assessment of left ventricular (LV) ejection fraction, LV global longitudinal strain, LV mass index, LV end-diastolic volume index, and LV end-systolic volume index at visit 5 were included. Longitudinal analysis included ARIC participants (N=14609) with measured GEH at visits 1 to 4. GEH was quantified by spatial ventricular gradient, QRS-T angle, and sum absolute QRS-T integral. Cross-sectional and longitudinal regressions were adjusted for manifest and subclinical cardiovascular disease. Having 4 abnormal GEH parameters was associated with a 6.4% (95% confidence interval, 5.5–7.3) LV ejection fraction decline, a 24.2 g/m2 (95% confidence interval, 21.5–26.9) increase in LV mass index, a 10.3 mL/m2 (95% confidence interval, 8.9–11.7) increase in LV end-diastolic volume index, and a 7.8 mL/m2 (95% confidence interval, 6.9–8.6) increase in LV end-systolic volume index. Altogether, clinical and ECG parameters accounted for approximately one third of LV volume and 20% of systolic function variability. The associations were significantly stronger in cardiovascular disease. Sum absolute QRS-T integral increased by 20 mV*ms for each 3-year period in participants who demonstrated LV dilatation at visit 5. Sudden cardiac death victims demonstrated rapid GEH worsening, whereas those with LV dysfunction demonstrated slow GEH worsening. Healthy aging was associated with a distinct pattern of spatial ventricular gradient azimuth decrement. CONCLUSIONS: GEH is a marker of subclinical abnormalities in cardiac structure and function.

    Original languageEnglish (US)
    Article numbere005961
    JournalCirculation: Arrhythmia and Electrophysiology
    Volume11
    Issue number3
    DOIs
    StatePublished - Mar 1 2018

    Fingerprint

    Stroke Volume
    Atherosclerosis
    Electrocardiography
    Confidence Intervals
    Cardiovascular Diseases
    Myocardial Contraction
    Sudden Cardiac Death
    Left Ventricular Dysfunction
    Dilatation

    Keywords

    • Atherosclerosis
    • Dilatation
    • Electrocardiography
    • Hypertrophy, left ventricular
    • Vectorcardiography

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

    Cite this

    Global ECG measures and cardiac structure and function the ARIC study (Atherosclerosis risk in communities). / Biering-Sørensen, Tor; Kabir, Muammar; Waks, Jonathan W.; Thomas, Jason; Post, Wendy S.; Soliman, Elsayed Z.; Buxton, Alfred E.; Shah, Amil M.; Solomon, Scott D.; Tereshchenko, Larisa.

    In: Circulation: Arrhythmia and Electrophysiology, Vol. 11, No. 3, e005961, 01.03.2018.

    Research output: Contribution to journalArticle

    Biering-Sørensen, T, Kabir, M, Waks, JW, Thomas, J, Post, WS, Soliman, EZ, Buxton, AE, Shah, AM, Solomon, SD & Tereshchenko, L 2018, 'Global ECG measures and cardiac structure and function the ARIC study (Atherosclerosis risk in communities)', Circulation: Arrhythmia and Electrophysiology, vol. 11, no. 3, e005961. https://doi.org/10.1161/CIRCEP.117.005961
    Biering-Sørensen, Tor ; Kabir, Muammar ; Waks, Jonathan W. ; Thomas, Jason ; Post, Wendy S. ; Soliman, Elsayed Z. ; Buxton, Alfred E. ; Shah, Amil M. ; Solomon, Scott D. ; Tereshchenko, Larisa. / Global ECG measures and cardiac structure and function the ARIC study (Atherosclerosis risk in communities). In: Circulation: Arrhythmia and Electrophysiology. 2018 ; Vol. 11, No. 3.
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    abstract = "BACKGROUND: Electric excitation initiates myocardial mechanical contraction and coordinates myocardial pumping. We hypothesized that ECG global electric heterogeneity (GEH) and its longitudinal changes are associated with cardiac structure and function. METHODS AND RESULTS: Participants from the ARIC study (Atherosclerosis Risk in Communities) (N=5114; 58{\%} female; 22{\%} blacks) with resting 12-lead ECGs (visits 1–5) and echocardiographic assessment of left ventricular (LV) ejection fraction, LV global longitudinal strain, LV mass index, LV end-diastolic volume index, and LV end-systolic volume index at visit 5 were included. Longitudinal analysis included ARIC participants (N=14609) with measured GEH at visits 1 to 4. GEH was quantified by spatial ventricular gradient, QRS-T angle, and sum absolute QRS-T integral. Cross-sectional and longitudinal regressions were adjusted for manifest and subclinical cardiovascular disease. Having 4 abnormal GEH parameters was associated with a 6.4{\%} (95{\%} confidence interval, 5.5–7.3) LV ejection fraction decline, a 24.2 g/m2 (95{\%} confidence interval, 21.5–26.9) increase in LV mass index, a 10.3 mL/m2 (95{\%} confidence interval, 8.9–11.7) increase in LV end-diastolic volume index, and a 7.8 mL/m2 (95{\%} confidence interval, 6.9–8.6) increase in LV end-systolic volume index. Altogether, clinical and ECG parameters accounted for approximately one third of LV volume and 20{\%} of systolic function variability. The associations were significantly stronger in cardiovascular disease. Sum absolute QRS-T integral increased by 20 mV*ms for each 3-year period in participants who demonstrated LV dilatation at visit 5. Sudden cardiac death victims demonstrated rapid GEH worsening, whereas those with LV dysfunction demonstrated slow GEH worsening. Healthy aging was associated with a distinct pattern of spatial ventricular gradient azimuth decrement. CONCLUSIONS: GEH is a marker of subclinical abnormalities in cardiac structure and function.",
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    AU - Biering-Sørensen, Tor

    AU - Kabir, Muammar

    AU - Waks, Jonathan W.

    AU - Thomas, Jason

    AU - Post, Wendy S.

    AU - Soliman, Elsayed Z.

    AU - Buxton, Alfred E.

    AU - Shah, Amil M.

    AU - Solomon, Scott D.

    AU - Tereshchenko, Larisa

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    N2 - BACKGROUND: Electric excitation initiates myocardial mechanical contraction and coordinates myocardial pumping. We hypothesized that ECG global electric heterogeneity (GEH) and its longitudinal changes are associated with cardiac structure and function. METHODS AND RESULTS: Participants from the ARIC study (Atherosclerosis Risk in Communities) (N=5114; 58% female; 22% blacks) with resting 12-lead ECGs (visits 1–5) and echocardiographic assessment of left ventricular (LV) ejection fraction, LV global longitudinal strain, LV mass index, LV end-diastolic volume index, and LV end-systolic volume index at visit 5 were included. Longitudinal analysis included ARIC participants (N=14609) with measured GEH at visits 1 to 4. GEH was quantified by spatial ventricular gradient, QRS-T angle, and sum absolute QRS-T integral. Cross-sectional and longitudinal regressions were adjusted for manifest and subclinical cardiovascular disease. Having 4 abnormal GEH parameters was associated with a 6.4% (95% confidence interval, 5.5–7.3) LV ejection fraction decline, a 24.2 g/m2 (95% confidence interval, 21.5–26.9) increase in LV mass index, a 10.3 mL/m2 (95% confidence interval, 8.9–11.7) increase in LV end-diastolic volume index, and a 7.8 mL/m2 (95% confidence interval, 6.9–8.6) increase in LV end-systolic volume index. Altogether, clinical and ECG parameters accounted for approximately one third of LV volume and 20% of systolic function variability. The associations were significantly stronger in cardiovascular disease. Sum absolute QRS-T integral increased by 20 mV*ms for each 3-year period in participants who demonstrated LV dilatation at visit 5. Sudden cardiac death victims demonstrated rapid GEH worsening, whereas those with LV dysfunction demonstrated slow GEH worsening. Healthy aging was associated with a distinct pattern of spatial ventricular gradient azimuth decrement. CONCLUSIONS: GEH is a marker of subclinical abnormalities in cardiac structure and function.

    AB - BACKGROUND: Electric excitation initiates myocardial mechanical contraction and coordinates myocardial pumping. We hypothesized that ECG global electric heterogeneity (GEH) and its longitudinal changes are associated with cardiac structure and function. METHODS AND RESULTS: Participants from the ARIC study (Atherosclerosis Risk in Communities) (N=5114; 58% female; 22% blacks) with resting 12-lead ECGs (visits 1–5) and echocardiographic assessment of left ventricular (LV) ejection fraction, LV global longitudinal strain, LV mass index, LV end-diastolic volume index, and LV end-systolic volume index at visit 5 were included. Longitudinal analysis included ARIC participants (N=14609) with measured GEH at visits 1 to 4. GEH was quantified by spatial ventricular gradient, QRS-T angle, and sum absolute QRS-T integral. Cross-sectional and longitudinal regressions were adjusted for manifest and subclinical cardiovascular disease. Having 4 abnormal GEH parameters was associated with a 6.4% (95% confidence interval, 5.5–7.3) LV ejection fraction decline, a 24.2 g/m2 (95% confidence interval, 21.5–26.9) increase in LV mass index, a 10.3 mL/m2 (95% confidence interval, 8.9–11.7) increase in LV end-diastolic volume index, and a 7.8 mL/m2 (95% confidence interval, 6.9–8.6) increase in LV end-systolic volume index. Altogether, clinical and ECG parameters accounted for approximately one third of LV volume and 20% of systolic function variability. The associations were significantly stronger in cardiovascular disease. Sum absolute QRS-T integral increased by 20 mV*ms for each 3-year period in participants who demonstrated LV dilatation at visit 5. Sudden cardiac death victims demonstrated rapid GEH worsening, whereas those with LV dysfunction demonstrated slow GEH worsening. Healthy aging was associated with a distinct pattern of spatial ventricular gradient azimuth decrement. CONCLUSIONS: GEH is a marker of subclinical abnormalities in cardiac structure and function.

    KW - Atherosclerosis

    KW - Dilatation

    KW - Electrocardiography

    KW - Hypertrophy, left ventricular

    KW - Vectorcardiography

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