Glioma FMISO PET/MR imaging concurrent with antiangiogenic therapy: Molecular imaging as a clinical tool in the burgeoning era of personalized medicine

Ramon F. Barajas, Kenneth A. Krohn, Jeanne M. Link, Randall A. Hawkins, Jennifer L. Clarke, Miguel H. Pampaloni, Soonmee Cha

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The purpose of this article is to provide a focused overview of the current use of positron emission tomography (PET) molecular imaging in the burgeoning era of personalized medicine in the treatment of patients with glioma. Specifically, we demonstrate the utility of PET imaging as a tool for personalized diagnosis and therapy by highlighting a case series of four patients with recurrent high grade glioma who underwent 18F-fluoromisonidazole (FMISO) PET/MR (magnetic resonance) imaging through the course of antiangiogenic therapy. Three distinct features were observed from this small cohort of patients. First, the presence of pseudoprogression was retrospectively associated with the absence of hypoxia. Second, a subgroup of patients with recurrent high grade glioma undergoing bevacizumab therapy demonstrated disease progression characterized by an enlarging nonenhancing mass with newly developed reduced diffusion, lack of hypoxia, and preserved cerebral blood volume. Finally, a reduction in hypoxic volume was observed concurrent with therapy in all patients with recurrent tumor, and markedly so in two patients that developed a nonenhancing reduced diffusion mass. This case series demonstrates how medical imaging has the potential to influence personalized medicine in several key aspects, especially involving molecular PET imaging for personalized diagnosis, patient specific disease prognosis, and therapeutic monitoring.

Original languageEnglish (US)
Article number24
JournalBiomedicines
Volume4
Issue number4
DOIs
StatePublished - Dec 1 2016

Keywords

  • ADC
  • Bevacizumab
  • FMISO
  • Glioma
  • MRI
  • PET
  • Progression
  • Pseudoprogression
  • Reduced diffusion

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Glioma FMISO PET/MR imaging concurrent with antiangiogenic therapy: Molecular imaging as a clinical tool in the burgeoning era of personalized medicine'. Together they form a unique fingerprint.

  • Cite this