Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice

Steven G. Kohama; James R. Goss; Thomas H. McNeill; Caleb E. Finch

doi:10.1016/0304-3940(94)11141-5

Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice

Steven G. Kohama, James R. Goss, Thomas H. McNeill, Caleb E. Finch

Oregon National Primate Research Center

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Glial fibrillary acidic protein (GFAP) increases during proestrus in astrocytes of the hypothalamic arcuate nucleus (ARC). These changes are associated with altered astrocyte-neuron contacts and synaptic remodelling, during preparation for the preovulatory gonadotrophin surge. This study of young C57BL/6J mice showed transient elevations of GFAP mRNA on proestrus in the ARC by in situ hybridization. Basal GFAP mRNA was regained within 18 h. We hypothesize that changes in astrocytic GFAP on proestrus result from elevations of GFAP mRNA that are, in turn, driven by ovarian secretions of estradiol.

Original language	English (US)
Pages (from-to)	164-166
Number of pages	3
Journal	Neuroscience Letters
Volume	183
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(94)11141-5
State	Published - Jan 9 1995

Keywords

Arcuate nucleus
Estrous cycle
Glial fibrillary acidic protein
In situ hybridization
Mice

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)11141-5

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title = "Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice",

abstract = "Glial fibrillary acidic protein (GFAP) increases during proestrus in astrocytes of the hypothalamic arcuate nucleus (ARC). These changes are associated with altered astrocyte-neuron contacts and synaptic remodelling, during preparation for the preovulatory gonadotrophin surge. This study of young C57BL/6J mice showed transient elevations of GFAP mRNA on proestrus in the ARC by in situ hybridization. Basal GFAP mRNA was regained within 18 h. We hypothesize that changes in astrocytic GFAP on proestrus result from elevations of GFAP mRNA that are, in turn, driven by ovarian secretions of estradiol.",

keywords = "Arcuate nucleus, Estrous cycle, Glial fibrillary acidic protein, In situ hybridization, Mice",

author = "Kohama, {Steven G.} and Goss, {James R.} and McNeill, {Thomas H.} and Finch, {Caleb E.}",

note = "Funding Information: We are grateful to Chris Anderson for skilful preparation of the figure. This research was supported by awards from the National Institute on Aging to CEF (AG-07909), to SGK (Training Grant AG-00093), and to THM (AG-00300).",

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doi = "10.1016/0304-3940(94)11141-5",

language = "English (US)",

volume = "183",

pages = "164--166",

journal = "Neuroscience Letters",

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T1 - Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice

AU - Kohama, Steven G.

AU - Goss, James R.

AU - McNeill, Thomas H.

AU - Finch, Caleb E.

N1 - Funding Information: We are grateful to Chris Anderson for skilful preparation of the figure. This research was supported by awards from the National Institute on Aging to CEF (AG-07909), to SGK (Training Grant AG-00093), and to THM (AG-00300).

PY - 1995/1/9

Y1 - 1995/1/9

N2 - Glial fibrillary acidic protein (GFAP) increases during proestrus in astrocytes of the hypothalamic arcuate nucleus (ARC). These changes are associated with altered astrocyte-neuron contacts and synaptic remodelling, during preparation for the preovulatory gonadotrophin surge. This study of young C57BL/6J mice showed transient elevations of GFAP mRNA on proestrus in the ARC by in situ hybridization. Basal GFAP mRNA was regained within 18 h. We hypothesize that changes in astrocytic GFAP on proestrus result from elevations of GFAP mRNA that are, in turn, driven by ovarian secretions of estradiol.

AB - Glial fibrillary acidic protein (GFAP) increases during proestrus in astrocytes of the hypothalamic arcuate nucleus (ARC). These changes are associated with altered astrocyte-neuron contacts and synaptic remodelling, during preparation for the preovulatory gonadotrophin surge. This study of young C57BL/6J mice showed transient elevations of GFAP mRNA on proestrus in the ARC by in situ hybridization. Basal GFAP mRNA was regained within 18 h. We hypothesize that changes in astrocytic GFAP on proestrus result from elevations of GFAP mRNA that are, in turn, driven by ovarian secretions of estradiol.

KW - Arcuate nucleus

KW - Estrous cycle

KW - Glial fibrillary acidic protein

KW - In situ hybridization

KW - Mice

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Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice

Abstract

Keywords

ASJC Scopus subject areas

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