Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice

Steven Kohama, James R. Goss, Thomas H. McNeill, Caleb E. Finch

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    Glial fibrillary acidic protein (GFAP) increases during proestrus in astrocytes of the hypothalamic arcuate nucleus (ARC). These changes are associated with altered astrocyte-neuron contacts and synaptic remodelling, during preparation for the preovulatory gonadotrophin surge. This study of young C57BL/6J mice showed transient elevations of GFAP mRNA on proestrus in the ARC by in situ hybridization. Basal GFAP mRNA was regained within 18 h. We hypothesize that changes in astrocytic GFAP on proestrus result from elevations of GFAP mRNA that are, in turn, driven by ovarian secretions of estradiol.

    Original languageEnglish (US)
    Pages (from-to)164-166
    Number of pages3
    JournalNeuroscience Letters
    Issue number3
    Publication statusPublished - Jan 9 1995



    • Arcuate nucleus
    • Estrous cycle
    • Glial fibrillary acidic protein
    • In situ hybridization
    • Mice

    ASJC Scopus subject areas

    • Neuroscience(all)

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