Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice

Steven Kohama, James R. Goss, Thomas H. McNeill, Caleb E. Finch

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    Glial fibrillary acidic protein (GFAP) increases during proestrus in astrocytes of the hypothalamic arcuate nucleus (ARC). These changes are associated with altered astrocyte-neuron contacts and synaptic remodelling, during preparation for the preovulatory gonadotrophin surge. This study of young C57BL/6J mice showed transient elevations of GFAP mRNA on proestrus in the ARC by in situ hybridization. Basal GFAP mRNA was regained within 18 h. We hypothesize that changes in astrocytic GFAP on proestrus result from elevations of GFAP mRNA that are, in turn, driven by ovarian secretions of estradiol.

    Original languageEnglish (US)
    Pages (from-to)164-166
    Number of pages3
    JournalNeuroscience Letters
    Volume183
    Issue number3
    DOIs
    StatePublished - Jan 9 1995

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    Proestrus
    Arcuate Nucleus of Hypothalamus
    Glial Fibrillary Acidic Protein
    Messenger RNA
    Astrocytes
    Gonadotropins
    Inbred C57BL Mouse
    In Situ Hybridization
    Estradiol
    Neurons

    Keywords

    • Arcuate nucleus
    • Estrous cycle
    • Glial fibrillary acidic protein
    • In situ hybridization
    • Mice

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice. / Kohama, Steven; Goss, James R.; McNeill, Thomas H.; Finch, Caleb E.

    In: Neuroscience Letters, Vol. 183, No. 3, 09.01.1995, p. 164-166.

    Research output: Contribution to journalArticle

    Kohama, Steven ; Goss, James R. ; McNeill, Thomas H. ; Finch, Caleb E. / Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice. In: Neuroscience Letters. 1995 ; Vol. 183, No. 3. pp. 164-166.
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