Glial cell component in retinoblastoma

Joseph L. Craft, Delia N. Sang, Thaddeus P. Dryja, Robert J. Brockhurst, Nancy L. Robinson, Daniel Albert

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The right eye of a 4-month-old girl with a large, unilateral, sporadic retinoblastoma was enucleated. The tumor was unusual because it contained Flexner-Wintersteiner rosettes with extremely large lumina. Smaller rosettes and undifferentiated tumor cells were observed within the lumina. Also of importance were cells resembling glial cells which were intermixed with more typical cuboidal retinoblastoma cells. These cells had electron microscopic features typical of glial cells and stained positively for glial fibrillary acidic protein in immunohistochemical studies. Rosettes and glial cells continued to be observed in the tumor carried in tissue culture through two passages over a 7-month period. This tumor is presented because of its unusual rosette structures and because it confirms recent reports describing a glial cell component in retinoblastoma.

Original languageEnglish (US)
JournalExperimental Eye Research
Volume40
Issue number5
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Retinoblastoma
Cellular Structures
Neuroglia
Neoplasms
Glial Fibrillary Acidic Protein
Electrons

Keywords

  • glial cells
  • retinoblastoma

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Craft, J. L., Sang, D. N., Dryja, T. P., Brockhurst, R. J., Robinson, N. L., & Albert, D. (1985). Glial cell component in retinoblastoma. Experimental Eye Research, 40(5). https://doi.org/10.1016/0014-4835(85)90134-4

Glial cell component in retinoblastoma. / Craft, Joseph L.; Sang, Delia N.; Dryja, Thaddeus P.; Brockhurst, Robert J.; Robinson, Nancy L.; Albert, Daniel.

In: Experimental Eye Research, Vol. 40, No. 5, 01.01.1985.

Research output: Contribution to journalArticle

Craft, JL, Sang, DN, Dryja, TP, Brockhurst, RJ, Robinson, NL & Albert, D 1985, 'Glial cell component in retinoblastoma', Experimental Eye Research, vol. 40, no. 5. https://doi.org/10.1016/0014-4835(85)90134-4
Craft JL, Sang DN, Dryja TP, Brockhurst RJ, Robinson NL, Albert D. Glial cell component in retinoblastoma. Experimental Eye Research. 1985 Jan 1;40(5). https://doi.org/10.1016/0014-4835(85)90134-4
Craft, Joseph L. ; Sang, Delia N. ; Dryja, Thaddeus P. ; Brockhurst, Robert J. ; Robinson, Nancy L. ; Albert, Daniel. / Glial cell component in retinoblastoma. In: Experimental Eye Research. 1985 ; Vol. 40, No. 5.
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