Glia-to-neuron signaling and the neuroendocrine control of female puberty

Sergio Ojeda, Vincent Prevot, Sabine Heger, Alejandro Lomniczi, Barbara Dziedzic, Alison Mungenast

    Research output: Contribution to journalArticle

    74 Citations (Scopus)

    Abstract

    The sine qua non event of puberty is an increase in pulsatile release of gonadotrophin hormone releasing hormone (GnRH). It is now clear that this increase and, therefore, the initiation of the pubertal process itself, require both changes in transsynaptic communication and the activation of glia-to-neuron signaling pathways. While neurons that utilize excitatory and inhibitory amino acids as transmitters represent major players in the transsynaptic control of puberty, glial cells utilize a combination of trophic factors and small cell-cell signaling molecules to regulate neuronal function and, thus, promote sexual development. A coordinated increase in glutamatergic transmission accompanied by a decrease in inhibitory GABAergic tone appears to initiate the transsynaptic cascade of events leading to the pubertal increase in GnRH release. Glial cells facilitate GnRH secretion via cell-cell signaling loops mainly initiated by members of the EGF and TGF- families of trophic factors, and brought about by either these factors themselves or by chemical messengers released in response to growth factor stimulation. In turn, a neuron-to-glia communication pathway mediated by excitatory amino acids serves to coordinate the simultaneous activation of transsynaptic and glia-to-neuron communication required for the advent of sexual maturity. A different - and perhaps higher - level of control may involve the transcriptional regulation of subordinate genes that, by contributing to neuroendocrine maturation, are required for the initiation of the pubertal process.

    Original languageEnglish (US)
    Pages (from-to)244-255
    Number of pages12
    JournalAnnals of Medicine
    Volume35
    Issue number4
    DOIs
    StatePublished - 2003

    Fingerprint

    Puberty
    Neuroglia
    Neurons
    Gonadotropin-Releasing Hormone
    Excitatory Amino Acids
    Hormones
    Sexual Development
    Epidermal Growth Factor
    Intercellular Signaling Peptides and Proteins
    Genes

    Keywords

    • Astroglial cells
    • Glial-neuronal communication
    • Growth factors
    • Hypothalamus
    • Onset of puberty
    • Sexual development

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Glia-to-neuron signaling and the neuroendocrine control of female puberty. / Ojeda, Sergio; Prevot, Vincent; Heger, Sabine; Lomniczi, Alejandro; Dziedzic, Barbara; Mungenast, Alison.

    In: Annals of Medicine, Vol. 35, No. 4, 2003, p. 244-255.

    Research output: Contribution to journalArticle

    Ojeda, Sergio ; Prevot, Vincent ; Heger, Sabine ; Lomniczi, Alejandro ; Dziedzic, Barbara ; Mungenast, Alison. / Glia-to-neuron signaling and the neuroendocrine control of female puberty. In: Annals of Medicine. 2003 ; Vol. 35, No. 4. pp. 244-255.
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