@inproceedings{8947c71a8abb4aa5a4471118536ff766,
title = "GIRK Channels: A Potential Link Between Learning and Addiction",
abstract = "The ability of drug-associated cues to reinitiate drug craving and seeking, even after long periods of abstinence, has led to the hypothesis that addiction represents a form of pathological learning, in which drugs of abuse hijack normal learning and memory processes to support long-term addictive behaviors. In this chapter, we review evidence suggesting that G protein-gated inwardly rectifying potassium (GIRK/Kir3) channels are one mechanism through which numerous drugs of abuse can modulate learning and memory processes. We will examine the role of GIRK channels in two forms of experience-dependent long-term changes in neuronal function: homeostatic plasticity and synaptic plasticity. We will also discuss how drug-induced changes in GIRK-mediated signaling can lead to changes that support the development and maintenance of addiction.",
keywords = "Addiction, Depotentiation, GIRK, Homeostatic plasticity, Kir3, Learning, Memory, Synaptic plasticity",
author = "Tipps, {Megan E.} and Buck, {Kari J.}",
note = "Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2015",
doi = "10.1016/bs.irn.2015.05.012",
language = "English (US)",
isbn = "9780128024584",
series = "International Review of Neurobiology",
publisher = "Academic Press Inc.",
pages = "239--277",
editor = "Harris, {R. Adron} and Peter Jenner",
booktitle = "International Review of Neurobiology - Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels, 2015",
}