Gilles de la Tourette Syndrome Is Not Linked to D2-Dopamine Receptor

Joel Gelernter, Andrew J. Pakstis, David L. Pauls, Roger Kurlan, Steven T. Gancher, Olivier Civelli, David Grandy, Kenneth K. Kidd

    Research output: Contribution to journalArticle

    53 Scopus citations

    Abstract

    Gilles de la Tourette syndrome has an important genetic component; the pathophysiology of this disorder may involve the dopamine system. We tested a D2-dopamine receptor (locus DRD2, recognized by probe hD2G1) for genetic linkage with Gilles de la Tourette syndrome. Using a genetic linkage map of the region of DRD2 on the long arm of chromosome 11 and restriction fragment length polymorphism data from a total of four markers (DRD2 itself, D11S84, D11S29, and PBGD), we were able to exclude linkage of this candidate gene and Gilles de la Tourette syndrome in two extended kindreds segregating for Gilles de la Tourette syndrome. This rules out causation of Gilles de la Tourette syndrome by mutation in DRD2 in the kindreds studied under the genetic assumptions we employed; use of the map and multipoint linkage analyses also allowed us to exclude a Gilles de la Tourette syndrome susceptibility locus from a larger genetic region.

    Original languageEnglish (US)
    Pages (from-to)1073-1077
    Number of pages5
    JournalArchives of General Psychiatry
    Volume47
    Issue number11
    DOIs
    StatePublished - Nov 1990

    ASJC Scopus subject areas

    • Arts and Humanities (miscellaneous)
    • Psychiatry and Mental health

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