Giant invasive prolactinomas

Fred Y. Murphy, David L. Vesely, Richard M. Jordan, Stevenson Flanigan, Peter O. Kohler

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Two of the largest prolactinomas ever documented that have been followed for nine and 10 years, respectively, demonstrate how aggressive prolactinomas may become and how difficult invasive prolactinomas are to treat. One of these prolactinomas invaded both internal auditory canals and simultaneously grew inferiorly, reducing the bony support of the skull and necessitating the patient to utilize both hands to hold his head up. The second patient's prolactinoma invaded the sphenoidal, ethmoidal, and cavernous sinuses. Both of these patients had neurosurgical debulking of their tumors followed by radiation therapy. Neither patient's prolactin levels decreased significantly during their first five years post-surgically, at which time bromocriptine was added. Since then, there has been a gradual lowering of serum prolactin levels and a decrease in the size of these tumors. These cases demonstrate that prolonged treatment and very large doses of bromocriptine may be necessary for tumor reduction in patients with invasive prolactinomas.

Original languageEnglish (US)
Pages (from-to)995-1002
Number of pages8
JournalThe American Journal of Medicine
Issue number5
StatePublished - Nov 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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