Giant invasive pituitary prolactinoma with falsely low serum prolactin

The significance of 'hook effect'

Maria Fleseriu, Michael Lee, Maria M. Pineyro, Mario Skugor, Sethu K. Reddy, Elias S. Siraj, Amir H. Hamrahian

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The authors report a case of a patient with giant, invasive skull base tumor extending to the parasellar area discovered incidentally during the work-up for decreased memory. The patient's neurological exam was otherwise unremarkable. Endocrine evaluation performed at a local hospital showed a moderate hyperprolactinemia 103 ng/ml (normal up to 20 ng/ml). Given the large size of the tumor, the elevated prolactin (PRL) was interpreted to be secondary to stalk effect and patient underwent debulking surgery through a transcranial approach. Immunostaining of the excised tumor tissue was strongly positive for prolactin. His prolactin was found to be 13,144 ng/ml in our lab after surgery confirming the diagnosis of invasive giant prolactinoma. The patient developed a complete right third, fourth and sixth nerve palsy postoperatively. He was started on Cabergoline with normalization of his prolactin level and more than 50% decrease in residual tumor size over 9 months periods. There has been no clinically significant improvement in his right eye ophthalmoplegia since surgery. This case highlights the importance of 'Hook Effect' resulting in falsely low prolactin level, which may have significant therapeutic implication.

Original languageEnglish (US)
Pages (from-to)41-43
Number of pages3
JournalJournal of Neuro-Oncology
Volume79
Issue number1
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Prolactinoma
Prolactin
Serum
Trochlear Nerve Diseases
Abducens Nerve Diseases
Oculomotor Nerve Diseases
Ophthalmoplegia
Neoplasms
Hyperprolactinemia
Skull Base
Residual Neoplasm

Keywords

  • Hook effect
  • Macroadenoma
  • Pituitary
  • Prolactin

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

Cite this

Giant invasive pituitary prolactinoma with falsely low serum prolactin : The significance of 'hook effect'. / Fleseriu, Maria; Lee, Michael; Pineyro, Maria M.; Skugor, Mario; Reddy, Sethu K.; Siraj, Elias S.; Hamrahian, Amir H.

In: Journal of Neuro-Oncology, Vol. 79, No. 1, 08.2006, p. 41-43.

Research output: Contribution to journalArticle

Fleseriu, Maria ; Lee, Michael ; Pineyro, Maria M. ; Skugor, Mario ; Reddy, Sethu K. ; Siraj, Elias S. ; Hamrahian, Amir H. / Giant invasive pituitary prolactinoma with falsely low serum prolactin : The significance of 'hook effect'. In: Journal of Neuro-Oncology. 2006 ; Vol. 79, No. 1. pp. 41-43.
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