Getting the message from the gene to the synapse: sorting and intracellular transport of RNA in neurons

Oswald Steward, Gary A. Banker

Research output: Contribution to journalReview article

220 Scopus citations

Abstract

A key question in cellular neurobiology is how neurons target molecules to cellular microdomains at a distance from the nucleus. Of special importance are the thousands of postsynaptic sites that form the basis for synaptic communication. Recent evidence suggests that an important aspect of molecular trafficking involves differential sorting, selective intracellular transport, and docking of particular mRNA molecules and associated protein synthetic machinery at postsynaptic sites. This offers the potential for local regulation of the production of key proteins in response to conditions at individual synapses. This article reviews what is known about the mechanisms of mRNA trafficking in neurons and in other cells ranging from oocytes to oligodendrocytes, and considers the possible role that mRNA trafficking and the resulting local synthesis of particular proteins may play in cellular function.

Original languageEnglish (US)
Pages (from-to)180-186
Number of pages7
JournalTrends in Neurosciences
Volume15
Issue number5
DOIs
StatePublished - May 1992

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Getting the message from the gene to the synapse: sorting and intracellular transport of RNA in neurons'. Together they form a unique fingerprint.

  • Cite this