Getting the message from the gene to the synapse

sorting and intracellular transport of RNA in neurons

Oswald Steward, Gary Banker

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

A key question in cellular neurobiology is how neurons target molecules to cellular microdomains at a distance from the nucleus. Of special importance are the thousands of postsynaptic sites that form the basis for synaptic communication. Recent evidence suggests that an important aspect of molecular trafficking involves differential sorting, selective intracellular transport, and docking of particular mRNA molecules and associated protein synthetic machinery at postsynaptic sites. This offers the potential for local regulation of the production of key proteins in response to conditions at individual synapses. This article reviews what is known about the mechanisms of mRNA trafficking in neurons and in other cells ranging from oocytes to oligodendrocytes, and considers the possible role that mRNA trafficking and the resulting local synthesis of particular proteins may play in cellular function.

Original languageEnglish (US)
Pages (from-to)180-186
Number of pages7
JournalTrends in Neurosciences
Volume15
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

RNA Transport
Synapses
Neurons
Messenger RNA
Genes
Proteins
Neurobiology
Oligodendroglia
Oocytes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Getting the message from the gene to the synapse : sorting and intracellular transport of RNA in neurons. / Steward, Oswald; Banker, Gary.

In: Trends in Neurosciences, Vol. 15, No. 5, 1992, p. 180-186.

Research output: Contribution to journalArticle

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