Gestational trophoblastic disease: Clinical and imaging features

Akram M. Shaaban, Maryam Rezvani, Reham R. Haroun, Anne M. Kennedy, Khaled M. Elsayes, Jeffrey D. Olpin, Mohamed E. Salama, Bryan Foster, Christine O. Menias

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Gestational trophoblastic disease (GTD) is a spectrum of both benign and malignant gestational tumors, including hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The latter four entities are referred to as gestational trophoblastic neoplasia (GTN). These conditions are aggressive with a propensity to widely metastasize. GTN can result in significant morbidity and mortality if left untreated. Early diagnosis of GTD is essential for prompt and successful management while preserving fertility. Initial diagnosis of GTD is based on a multifactorial approach consisting of clinical features, serial quantitative human chorionic gonadotropin (β-hCG) titers, and imaging findings. Ultrasonography (US) is the modality of choice for initial diagnosis of complete hydatidiform mole and can provide an invaluable means of local surveillance after treatment. The performance of US in diagnosing all molar pregnancies is surprisingly poor, predominantly due to the difficulty in differentiating partial hydatidiform mole from nonmolar abortion and retained products of conception. While GTN after a molar pregnancy is usually diagnosed with serial β-hCG titers, imaging plays an important role in evaluation of local extent of disease and systemic surveillance. Imaging also plays a crucial role in detection and management of complications, such as uterine and pulmonary arteriovenous fistulas. Familiarity with the pathogenesis, classification, imaging features, and treatment of these tumors can aid in radiologic diagnosis and guide appropriate management.

Original languageEnglish (US)
Pages (from-to)681-700
Number of pages20
JournalRadiographics
Volume37
Issue number2
DOIs
StatePublished - Mar 1 2017

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Gestational Trophoblastic Disease
Hydatidiform Mole
Ultrasonography
Placental Site Trophoblastic Tumor
Invasive Hydatidiform Mole
Trophoblastic Neoplasms
Choriocarcinoma
Chorionic Gonadotropin
Fertility
Early Diagnosis
Neoplasms
Morbidity
Mortality

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Shaaban, A. M., Rezvani, M., Haroun, R. R., Kennedy, A. M., Elsayes, K. M., Olpin, J. D., ... Menias, C. O. (2017). Gestational trophoblastic disease: Clinical and imaging features. Radiographics, 37(2), 681-700. https://doi.org/10.1148/rg.2017160140

Gestational trophoblastic disease : Clinical and imaging features. / Shaaban, Akram M.; Rezvani, Maryam; Haroun, Reham R.; Kennedy, Anne M.; Elsayes, Khaled M.; Olpin, Jeffrey D.; Salama, Mohamed E.; Foster, Bryan; Menias, Christine O.

In: Radiographics, Vol. 37, No. 2, 01.03.2017, p. 681-700.

Research output: Contribution to journalArticle

Shaaban, AM, Rezvani, M, Haroun, RR, Kennedy, AM, Elsayes, KM, Olpin, JD, Salama, ME, Foster, B & Menias, CO 2017, 'Gestational trophoblastic disease: Clinical and imaging features', Radiographics, vol. 37, no. 2, pp. 681-700. https://doi.org/10.1148/rg.2017160140
Shaaban AM, Rezvani M, Haroun RR, Kennedy AM, Elsayes KM, Olpin JD et al. Gestational trophoblastic disease: Clinical and imaging features. Radiographics. 2017 Mar 1;37(2):681-700. https://doi.org/10.1148/rg.2017160140
Shaaban, Akram M. ; Rezvani, Maryam ; Haroun, Reham R. ; Kennedy, Anne M. ; Elsayes, Khaled M. ; Olpin, Jeffrey D. ; Salama, Mohamed E. ; Foster, Bryan ; Menias, Christine O. / Gestational trophoblastic disease : Clinical and imaging features. In: Radiographics. 2017 ; Vol. 37, No. 2. pp. 681-700.
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