TY - JOUR
T1 - Gestational age-specific neonatal morbidity among pregnancies complicated by advanced maternal age
T2 - A population-based retrospective cohort study
AU - Valent, Amy M.
AU - Newman, Tondra
AU - Chen, Aimin
AU - Thompson, Amy
AU - Defranco, Emily
N1 - Publisher Copyright:
© 2015 Informa UK Ltd.
PY - 2016/5/2
Y1 - 2016/5/2
N2 - Objective: Compare significant neonatal morbidity frequency differences in advanced maternal age (AMA) versus non-AMA pregnancies, assessing which gestational week is associated with the lowest morbidity risk.Methods: Population-based retrospective cohort study. Adverse neonatal outcome frequency differences were stratified by each week of gestation. Multivariate logistic regression estimated the relative risk (RR) of composite neonatal morbidity for women aged 35-39, 40-44, 45-49 and 50-55 versus 18-34 years, adjusted sequentially for relevant risk factors.Results: Neonatal morbidity decreased with each advancing week of term gestation, lowest at 39 weeks for all the groups. Adverse neonatal outcome risk for births to AMA women increased at 40 weeks: 35-39 years adjRR 1.12 [1.01-1.24] and ≥40 years 1.24 [1.01-1.52]. Each older maternal age category had increased risk for overall neonatal morbidity: 35-39 years adjRR 1.11 [95% CI 1.08-1.15], 40-44 years 1.21 [95% CI 1.14-1.29] and 45-49 years 1.34 [95% CI 1.05-1.69].Conclusions: Lowest neonatal morbidity risk is at 39-week gestation with a significantly increased risk observed thereafter, especially in women ≥40 years.
AB - Objective: Compare significant neonatal morbidity frequency differences in advanced maternal age (AMA) versus non-AMA pregnancies, assessing which gestational week is associated with the lowest morbidity risk.Methods: Population-based retrospective cohort study. Adverse neonatal outcome frequency differences were stratified by each week of gestation. Multivariate logistic regression estimated the relative risk (RR) of composite neonatal morbidity for women aged 35-39, 40-44, 45-49 and 50-55 versus 18-34 years, adjusted sequentially for relevant risk factors.Results: Neonatal morbidity decreased with each advancing week of term gestation, lowest at 39 weeks for all the groups. Adverse neonatal outcome risk for births to AMA women increased at 40 weeks: 35-39 years adjRR 1.12 [1.01-1.24] and ≥40 years 1.24 [1.01-1.52]. Each older maternal age category had increased risk for overall neonatal morbidity: 35-39 years adjRR 1.11 [95% CI 1.08-1.15], 40-44 years 1.21 [95% CI 1.14-1.29] and 45-49 years 1.34 [95% CI 1.05-1.69].Conclusions: Lowest neonatal morbidity risk is at 39-week gestation with a significantly increased risk observed thereafter, especially in women ≥40 years.
KW - Advanced maternal age
KW - adverse neonatal outcomes
KW - gestational week of delivery
UR - http://www.scopus.com/inward/record.url?scp=84958231546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958231546&partnerID=8YFLogxK
U2 - 10.3109/14767058.2015.1051955
DO - 10.3109/14767058.2015.1051955
M3 - Article
C2 - 26043643
AN - SCOPUS:84958231546
SN - 1476-7058
VL - 29
SP - 1485
EP - 1490
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 9
ER -