Gestational age correlates with skin reflectance in newborn infants of 24-42 weeks gestation

Cynthia J. Lynn, Iyad S. Saidi, David G. Oelberg, Steven Jacques

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Accurate gestational age determination is limited in very low birthweight infants using neurological and physical assessments. As one of the markers of intrauterine development, skin maturation is assessed qualitatively by pediatricians. Based on this observation, we hypothesize that skin reflec-tance relates directly to gestational age. Light was delivered and collected from the skin through a topically placed optical patch. Reflected light was detected by the spectrophotometer and corrected by an adjacent laptop computer to yield the true total diffuse reflectance as a function of wavelength between 380-820 nm. The calculated reflectance at 837 nm (R837) where it is independent of melanin, was determined by extrapolation from the reflectance at 650 and 750 nm. Sixty-four neonates of different races with gestational ages of 24-42 weeks were studied at 2-151 h of age. R837 was related exponentially to gestational age (GA) by the equation R837 = Rmax 1-exp[-(GA - G0)/ԏ], where Rmax is the maximal value of R837, G0 is an apparent delay time before dermal scattering increases rapidly, and ԏ a time constant, r = 0.88, p<0.001. In summary, the extrapolated skin reflectance offers a quantitative and objective assessment of gestational age which is independent of melanin and sex.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalNeonatology
Volume64
Issue number2-3
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

imiquimod
Gestational Age
Newborn Infant
Pregnancy
Skin
Melanins
Light

Keywords

  • Gestational age
  • Reflectance
  • Spectroscopy

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Gestational age correlates with skin reflectance in newborn infants of 24-42 weeks gestation. / Lynn, Cynthia J.; Saidi, Iyad S.; Oelberg, David G.; Jacques, Steven.

In: Neonatology, Vol. 64, No. 2-3, 1993, p. 69-75.

Research output: Contribution to journalArticle

Lynn, Cynthia J. ; Saidi, Iyad S. ; Oelberg, David G. ; Jacques, Steven. / Gestational age correlates with skin reflectance in newborn infants of 24-42 weeks gestation. In: Neonatology. 1993 ; Vol. 64, No. 2-3. pp. 69-75.
@article{110d6b8871fc4c4aaac41f3073afe32c,
title = "Gestational age correlates with skin reflectance in newborn infants of 24-42 weeks gestation",
abstract = "Accurate gestational age determination is limited in very low birthweight infants using neurological and physical assessments. As one of the markers of intrauterine development, skin maturation is assessed qualitatively by pediatricians. Based on this observation, we hypothesize that skin reflec-tance relates directly to gestational age. Light was delivered and collected from the skin through a topically placed optical patch. Reflected light was detected by the spectrophotometer and corrected by an adjacent laptop computer to yield the true total diffuse reflectance as a function of wavelength between 380-820 nm. The calculated reflectance at 837 nm (R837) where it is independent of melanin, was determined by extrapolation from the reflectance at 650 and 750 nm. Sixty-four neonates of different races with gestational ages of 24-42 weeks were studied at 2-151 h of age. R837 was related exponentially to gestational age (GA) by the equation R837 = Rmax 1-exp[-(GA - G0)/ԏ], where Rmax is the maximal value of R837, G0 is an apparent delay time before dermal scattering increases rapidly, and ԏ a time constant, r = 0.88, p<0.001. In summary, the extrapolated skin reflectance offers a quantitative and objective assessment of gestational age which is independent of melanin and sex.",
keywords = "Gestational age, Reflectance, Spectroscopy",
author = "Lynn, {Cynthia J.} and Saidi, {Iyad S.} and Oelberg, {David G.} and Steven Jacques",
year = "1993",
doi = "10.1159/000243973",
language = "English (US)",
volume = "64",
pages = "69--75",
journal = "Neonatology",
issn = "1661-7800",
publisher = "S. Karger AG",
number = "2-3",

}

TY - JOUR

T1 - Gestational age correlates with skin reflectance in newborn infants of 24-42 weeks gestation

AU - Lynn, Cynthia J.

AU - Saidi, Iyad S.

AU - Oelberg, David G.

AU - Jacques, Steven

PY - 1993

Y1 - 1993

N2 - Accurate gestational age determination is limited in very low birthweight infants using neurological and physical assessments. As one of the markers of intrauterine development, skin maturation is assessed qualitatively by pediatricians. Based on this observation, we hypothesize that skin reflec-tance relates directly to gestational age. Light was delivered and collected from the skin through a topically placed optical patch. Reflected light was detected by the spectrophotometer and corrected by an adjacent laptop computer to yield the true total diffuse reflectance as a function of wavelength between 380-820 nm. The calculated reflectance at 837 nm (R837) where it is independent of melanin, was determined by extrapolation from the reflectance at 650 and 750 nm. Sixty-four neonates of different races with gestational ages of 24-42 weeks were studied at 2-151 h of age. R837 was related exponentially to gestational age (GA) by the equation R837 = Rmax 1-exp[-(GA - G0)/ԏ], where Rmax is the maximal value of R837, G0 is an apparent delay time before dermal scattering increases rapidly, and ԏ a time constant, r = 0.88, p<0.001. In summary, the extrapolated skin reflectance offers a quantitative and objective assessment of gestational age which is independent of melanin and sex.

AB - Accurate gestational age determination is limited in very low birthweight infants using neurological and physical assessments. As one of the markers of intrauterine development, skin maturation is assessed qualitatively by pediatricians. Based on this observation, we hypothesize that skin reflec-tance relates directly to gestational age. Light was delivered and collected from the skin through a topically placed optical patch. Reflected light was detected by the spectrophotometer and corrected by an adjacent laptop computer to yield the true total diffuse reflectance as a function of wavelength between 380-820 nm. The calculated reflectance at 837 nm (R837) where it is independent of melanin, was determined by extrapolation from the reflectance at 650 and 750 nm. Sixty-four neonates of different races with gestational ages of 24-42 weeks were studied at 2-151 h of age. R837 was related exponentially to gestational age (GA) by the equation R837 = Rmax 1-exp[-(GA - G0)/ԏ], where Rmax is the maximal value of R837, G0 is an apparent delay time before dermal scattering increases rapidly, and ԏ a time constant, r = 0.88, p<0.001. In summary, the extrapolated skin reflectance offers a quantitative and objective assessment of gestational age which is independent of melanin and sex.

KW - Gestational age

KW - Reflectance

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=0027377434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027377434&partnerID=8YFLogxK

U2 - 10.1159/000243973

DO - 10.1159/000243973

M3 - Article

C2 - 8260548

AN - SCOPUS:0027377434

VL - 64

SP - 69

EP - 75

JO - Neonatology

JF - Neonatology

SN - 1661-7800

IS - 2-3

ER -