Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1

Kenneth D. Poss, Alex Nechiporuk, Keith F. Stringer, Charles Lee, Mark T. Keating

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.

Original languageEnglish (US)
Pages (from-to)1527-1532
Number of pages6
JournalGenes and Development
Volume18
Issue number13
DOIs
StatePublished - Jul 1 2004

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Keywords

  • Aneuploidy
  • Meiosis
  • Mps1
  • Nondisjunction
  • Spindle checkpoint
  • Zebrafish

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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