Geographical variations in the prevalence of atopic sensitization in six study sites across Canada

M. Chan-Yeung, N. R. Anthonisen, M. R. Becklake, D. Bowie, A (Sonia) Buist, H. Dimich-Ward, P. Ernst, M. R. Sears, H. C. Siersted, L. Sweet, L. Van Til, J. Manfreda

Research output: Contribution to journalArticle

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Abstract

Background: Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey-1 (ECRHS-1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS-1 centers. Methods: Adults aged 20-44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. Results: The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% [95% C.I.51.3-59.9] in Prince Edward Island, highest 66.0 [61.7-70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57% [52.3-61.8]) was close to that of Portland, Oregon (52.1% [46.2-58.0]). Conclusion: There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.

Original languageEnglish (US)
Pages (from-to)1404-1413
Number of pages10
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume65
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Canada
Allergens
European Union
Poaceae
Health Surveys
Prince Edward Island
Asthma
Phleum
Dermatophagoides farinae
Dermatophagoides Antigens
Cladosporium
Ambrosia
Alternaria
Betula
Cockroaches
Aspergillus fumigatus
Penicillium
Olea
Skin Tests
Hypersensitivity

Keywords

  • Atopy
  • Canada
  • Geographical variations
  • Prevalence

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. / Chan-Yeung, M.; Anthonisen, N. R.; Becklake, M. R.; Bowie, D.; Buist, A (Sonia); Dimich-Ward, H.; Ernst, P.; Sears, M. R.; Siersted, H. C.; Sweet, L.; Van Til, L.; Manfreda, J.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 65, No. 11, 11.2010, p. 1404-1413.

Research output: Contribution to journalArticle

Chan-Yeung, M, Anthonisen, NR, Becklake, MR, Bowie, D, Buist, AS, Dimich-Ward, H, Ernst, P, Sears, MR, Siersted, HC, Sweet, L, Van Til, L & Manfreda, J 2010, 'Geographical variations in the prevalence of atopic sensitization in six study sites across Canada', Allergy: European Journal of Allergy and Clinical Immunology, vol. 65, no. 11, pp. 1404-1413. https://doi.org/10.1111/j.1398-9995.2010.02399.x
Chan-Yeung, M. ; Anthonisen, N. R. ; Becklake, M. R. ; Bowie, D. ; Buist, A (Sonia) ; Dimich-Ward, H. ; Ernst, P. ; Sears, M. R. ; Siersted, H. C. ; Sweet, L. ; Van Til, L. ; Manfreda, J. / Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. In: Allergy: European Journal of Allergy and Clinical Immunology. 2010 ; Vol. 65, No. 11. pp. 1404-1413.
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abstract = "Background: Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey-1 (ECRHS-1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS-1 centers. Methods: Adults aged 20-44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. Results: The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7{\%}. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6{\%} [95{\%} C.I.51.3-59.9] in Prince Edward Island, highest 66.0 [61.7-70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57{\%} compared with 35.2{\%} overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57{\%} [52.3-61.8]) was close to that of Portland, Oregon (52.1{\%} [46.2-58.0]). Conclusion: There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.",
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AU - Buist, A (Sonia)

AU - Dimich-Ward, H.

AU - Ernst, P.

AU - Sears, M. R.

AU - Siersted, H. C.

AU - Sweet, L.

AU - Van Til, L.

AU - Manfreda, J.

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N2 - Background: Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey-1 (ECRHS-1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS-1 centers. Methods: Adults aged 20-44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. Results: The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% [95% C.I.51.3-59.9] in Prince Edward Island, highest 66.0 [61.7-70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57% [52.3-61.8]) was close to that of Portland, Oregon (52.1% [46.2-58.0]). Conclusion: There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.

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