Genotypic composition of different tissues and organs in BALB/s----C57BL/10 and BALB/c----B10.D2 mice in which chimeric drift was discovered in peripheral blood, erythrocyte population was studied. The proportion of cells of parental components was defined visually in coat, by electrophoresis of allozyme variants at the Gpi-1 locus in blood, spleen, brain, by differential C-staining of X and Y chromosome in cells of bone marrow and by mating of chimeras with BALB/c mice in gametes population. Chimeric drift in the erythrocyte population is not caused by advantage of BALB/c parental component over C57BL parental component in embryonal or postnatal development of whole chimeric organism, but result from selective advantage of hemopoietic BALB/c cells over C57BL cells in chimeric hemopoietic organs.
|Translated title of the contribution||Genotypic status of different tissues and organs in aggregated chimeras of BALB/c----C57BL/10 and BALB/c----B10.D2 with discovered chimeric drift|
|Number of pages||4|
|Journal||Byulleten Eksperimentalnoi Biologii i Meditsiny|
|State||Published - Oct 1 1988|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)